Dosing and uses of Paludrine (proguanil)
Adult dosage forms and strengths
Available in the US/Canada as a combo with atovaquone. Monotherapy info for reference only
400 mg (with 1 g atovaquone) PO qD x3 days
Prevention
200 mg PO qD, Or
100 mg (with 250 mg atovaquone) PO qd
Other Indications & Uses
Malaria (P. falciparum)
Pediatric dosage forms and strengths
11-20 kg: 100 mg
21-30 kg: 200 mg
31-40 kg: 300 mg
All PO qD x3 days
Prevention
<2 years old: 50 mg
2-6 years old: 100 mg
7-10 years old: 150 mg
>10 years old: 200 mg
All PO qd
Paludrine (proguanil) adverse (side) effects
>10%
Abdominal pain (33% children)
Headache (22% adults, 19% children)
Increased LFT's (17%)
Myalgia (12% adults)
Nausea (12%)
1-10%
Abdominal pain (9% adults)
Back pain (8% adults)
Upper respiratory tract infection (8% adults)
Cough (6% adults, 9% children)
Flu-like syndrome (2% adults, 9% children)
Vomiting (1% adults, 7% children)
Diarrhea (6% adults, 2% children)
Fever (5% adults, 6% children)
Anorexia (5%)
Dyspepsia (3% adults)
Gastritis (3% adults)
Frequency not defined
Neutropenia
Pancytopenia
Hepatitis (rare )
Liver failure (rare)
Anaphylaxis (rare )
Immune hypersensitivity reaction
Erythema multiforme (rare )
Stevens-Johnson syndrome (rare )
Warnings
Contraindications
Hypersensitivity to proguanil or atovaquone
Avoid during breast-feeding
Cautions
For acute malaria, admin atovaquone concomitantly
For malaria prevention, admin chloroquine phosphate or atovaquone concomitantly
Pregnancy and lactation
Pregnancy category: unknown
Lactation: unknown
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Paludrine (proguanil)
Metabolism: N/A
Excretion: N/A
Mechanism of action
AntimalariaL
