nystatin topical (Mycostatin topical, Pediaderm AF, PediDri): Dosing and Uses
Classes: Antifungals, Topical
Dosing and uses of Mycostatin topical, Pediaderm AF (nystatin topical)
Adult dosage forms and strengths
cream/ointment/powder
- 100,000unit/g
Mucocutaneous Infection
Apply to affected area q8-12hr for 2 weeks
See also combo with triamcinolone
Vaginal Infections
Insert 1 tablet/day qHS for 2 weeks
Administration
Cream preferred to ointment in candidiasis involving intertriginous areas
Moist lesions best treated with powder
Pediatric dosage forms and strengths
cream/ointment/powder
- 100,000unit/g
Mucocutaneous Infection
Apply to affected area q8-12hr for 2 weeks
Mycostatin topical, Pediaderm AF (nystatin topical) adverse (side) effects
Frequency not defined
Nontoxic; well tolerated by all age groups
Contact dermatitis
Stevens-Johnson syndrome
Acneiform eruption (rare)
Warnings
Contraindications
Hypersensitivity
Ophthalmic use
Pregnancy and lactation
Pregnancy category: B
Lactation: No studies
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Mycostatin topical, Pediaderm AF (nystatin topical)
Mechanism of action
Binds to fungal cell membrane sterols; as a result, the membrane no longer functions as a selective barrier, and potassium and other cellular constituents are lost
Absorption
Not from intact skin or mucous membrane