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Dosing and uses of Nylidrin

 

Adult dosage forms and strengths

tablet

  • 6mg

 

Peripheral Vascular Disorders

12-48 mg/day divided TID/QID PO

 

Organic Mental Disorders

12-24 mg/day divided TID/QID PO

 

Pediatric dosage forms and strengths

N/A

 

Nylidrin adverse (side) effects

Frequency not defined

Dizziness

Nausea/Vomiting

Palpitations

Postural hypotension

Trembling

 

Warnings

Contraindications

Recent MI, progressive angina

Paroxysmal tachycardia

Thyrotoxicosis

 

Cautions

Cardiac disease (eg, tachyarrhythmias, uncompensated CHF)

 

Pregnancy and lactation

Pregnancy category: weigh risk/benefit

Lactation: no info, weigh risk/benefit

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Nylidrin

Metabolism: N/A

Excretion: N/A

 

Mechanism of action

Peripheral vascular disorders: beta receptor stimulator; dilates skeletal muscle arterioles & increases cardiac output

Mechanism of psychopharmacologic actions not known