Dosing and uses of Nozin Nasal Sanitizer Advanced Antiseptic (ethyl alcohol intranasal)
Adult dosage forms and strengths
nasal swaB
- 62% (0.5mL prefilled ampule [POPswab])
- Inactive ingredients: jojoba, orange oil, coconut oil, lauric acid, benzalkonium chloride, and vitamin E
Nasal Bacterial Decolonization
Used for nasal decolonization as part of infection control measures to reduce nasal carriage bacteria (eg, S aureus) to lower the risk of nasal pathogen transmission
Swab nose as directed; not to exceed 4 times/day (see Administration)
Dosing Considerations
Use in healthcare providers
- Hospital healthcare providers who tested positive for S aureus nasal carriage were treated with 3 applications at 4-hr intervals during the workday
- Antiseptic use reduced colony forming units from baseline by 99% (median) and 82% (mean) (P <0.001) compared with placebo
- Total bacterial colony forming units were reduced by 91% (median) and 71% (mean) (P <0.001) compared with placebo
- Am J Infect Control. 2014 August;42(8):841-846
Use in other populations
- Part of postoperative/discharge care in patients and caregivers who are carriers
- Use in S aureus nasal carriers instead of isolation
Pediatric dosage forms and strengths
nasal swaB
- 62% (0.5mL prefilled ampule [POPswab])
- Inactive ingredients: jojoba, orange oil, coconut oil, lauric acid, benzalkonium chloride, and vitamin E
Nasal Bacterial Decolonization
Used for nasal decolonization as part of infection control measures to reduce nasal carriage bacteria (eg, S aureus) to lower the risk of nasal pathogen transmission
Swab nose as directed; not to exceed 4 times/day (see Administration)
Dosing Considerations
Use in healthcare providers
- Hospital healthcare providers who tested positive for S aureus nasal carriage were treated with 3 applications at 4-hr intervals during the workday
- Antiseptic use reduced colony forming units from baseline by 99% (median) and 82% (mean) (P <0.001) compared with placebo
- Total bacterial colony forming units were reduced by 91% (median) and 71% (mean) (P <0.001) compared with placebo
- Am J Infect Control. 2014 August;42(8):841-846
Use in other populations
- Part of postoperative/discharge care in patients and caregivers who are carriers
- Use in S aureus nasal carriers instead of isolation
Nozin Nasal Sanitizer Advanced Antiseptic (ethyl alcohol intranasal) adverse (side) effects
Frequency not defined
Irritation
Erythema
Warnings
Contraindications
Hypersensitivity
Cautions
Do not use in the eyes, on mucous membranes, with history of nasal bleeding or irritation, or if allergic to any of the ingredients
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown if distributed in human breast milk
Pregnant or breastfeeding patients should seek advice of a healthcare professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Nozin Nasal Sanitizer Advanced Antiseptic (ethyl alcohol intranasal)
Mechanism of action
Nonantibiotic antiseptic (ie, ethyl alcohol)
Used as part of an overall infection control plan to decolonize Staphylococcus aureus and other bacteria in the nasal cavity
Administration
Intranasal Administration
1. Flip ampule around in paper sleeve to expose swab tip
2. Shake welL
3. With sleeve on ampule, crush at dot to pop, then squeeze to wet swab tip
4. Swab around nostril rims 4 times in each direction
5. Caution: Do not extend in nose beyond swab tip; apply to skin only
6. Discard after single use
Storage
Store in cool, dry place between 59-84°F
