salicylic acid acne (Neutrogena Body Clear Body Wash, Neutrogena Oil-Free Acne Wash, Neutrogena Oil-Free Acne Stress Control, Neutrogena Oil-Free Acne Wash Foam Cleanser, Neutrogena Rapid Clear Acne Defense Face Lotion, Neutrogena Rapid Clear Acne Eliminating Spot Gel, Clean and Clear Advantage 3-in1 Foaming Acne wash, Clean and Clear Deep Cleaning Astringent, Clean and Clear Blackhead Eraser Scrub, Clean and Clear Dual Action Moisturizer, Clean and Clear Advantage Mark Treatment, Clean and Clear Advantage Acne Control Moisturizer, Oxy Clinical Advanced Face Wash, Oxy Maximum Face Scrub, Oxy Maximum Hydrating Body Wash, Oxy Maximum Cleansing Pads, Oxy Clinical Hydrating Therapy, Oxy Clinical Foaming Face Wash, Palmers Skin Success Acne Medication Cleanser, Zapzyt Acne Wash, Zapzyt Pore Clearing Scrub, Clearasil Ultra Rapid Action Face Scrub, Clearasil Daily Clear Daily Pore Cleansing Pads, Clearasil Daily Clear Vanishing Acne Treatment Cream, Benzac Skin Balancing Foaming Cleanser 0.5%, Benzac Intensive Spot Treatment 2%, Benzac Blemish Clearing Hydrator 0.5%, Benzac Skin Refining Mask)
Classes: Acne Agents, Topical
Dosing and uses of Neutrogena, Clean and Clear (salicylic acid acne)
Adult dosage forms and strengths
topical lotion
- 0.5%
topical cleanser
- 2%
- 0.5%
topical toner/astringent
- 2%
topical geL
- 2%
topical pads
- 2%
topical cream
- 2%
- 6%
topical foam/aerosoL
- 6%
topical bar soap
- 2%
topical mask
- 0.5% plus East Indian sandalwood oil and French clay
Acne Vulgaris
Cleansers: Twice daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly
Scrubs: Once daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly
Cream/foam/gel: After cleansing, apply sparingly to affected area(s) up to TId
Pads/Wipes: After cleansing, gently wipe face & neck w/ pad; do not rinse
Shower/bath gels/soap: Use in shower once daily; massage over skin; rinse welL
Product content varies, check individual labeling
Pediatric dosage forms and strengths
topical lotion
- 0.5%
topical cleanser
- 0.5%
- 2%
topical toner/astringent
- 2%
topical geL
- 2%
topical pads
- 2%
topical cream
- 2%
- 6%
topical foam/aerosoL
- 6%
topical bar soap
- 2%
topical mask
- 0.5% plus East Indian sandalwood oil and French clay
Acne Vulgaris
Adolescents: As adults
Cleansers: Twice daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly
Scrubs: Once daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly
Cream/foam/gel: After cleansing, apply sparingly to affected area(s) up to TId
Pads/Wipes: After cleansing, gently wipe face & neck w/ pad; do not rinse
Shower/bath gels/soap: Use in shower once daily; massage over skin; rinse welL
Product content varies, check individual labeling
Neutrogena, Clean and Clear (salicylic acid acne) adverse (side) effects
Frequency not defined
Stinging/burning of skin
Desquamation
Warnings
Contraindications
Hypersensitivity
Moles
Birthmarks
Eyes
Facial warts or warts on mucous membranes
Warts with hair growing from them
Genitals
Infected, reddened, or irritated areas
Cautions
Topical use only
Avoid contact with eyes
Serious allergic reactions
- Rare but serious and potentially life-threatening allergic reactions or severe irritation reported
- Instruct patients to stop using their topical acne product and seek emergency medical attention immediately if they experience hypersensitivity reactions (eg, throat tightness, difficulty breathing, feeling fain, or swelling of the eyes, face, lips, or tongue)
- Also instruct patients to stop using the product if they develop hives or itching
- These serious hypersensitivity reactions differ from the local skin irritation that may occur at the product application site (eg, redness, burning, dryness, itching, peeling, or slight swelling)
Pregnancy and lactation
Pregnancy category: C
Lactation: unknown
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Neutrogena, Clean and Clear (salicylic acid acne)
Mechanism of action
Comedolytic agent. Inhibits the formation of comedones resulting from oil and skin cells that become trapped in the pore.
Its lipophilic characteristics facilitate the peeling of the exterior layer of the dermis and opens follicles that are plugged. This leads skin cells to renew their cell cycle of proliferation and differentiation.
Salicylic acid can interfere with the arachidonic acid cascade of the inflammatory process. This action results in the reduction of inflammatory acne lesions.
Administration
Instructions
Before using a topical acne product for the first time, patients should apply a small amount to 1 or 2 small affected areas of the skin for 3 days, if no discomfort/allergy occurs, then the product can be used according to the directions
