phenylephrine nasal (NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray)

Dosing and uses of NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray (phenylephrine nasal)

• Adult
• Pediatric

 

Adult dosage forms and strengths

nasal spray

• 0.125%
• 0.25%
• 0.5%
• 1%

 

Nasal Congestion

Instill 2-3 sprays or 2-3 gtt q4hr of 0.25-0.1% solution PRN; not to exceed 3 days

 

Pediatric dosage forms and strengths

nasal spray

• 0.125%
• 0.25%
• 0.5%
• 1%

 

Nasal Congestion

<2 years

• Consult a physician

2-6 years

• 1-3 gtt intranasally q2-4hr of 0.125% solution PRN; not to exceed 3 days

6-12 years

• 2-3 gtt intranasally q4hr of 0.25% solution PRN; not to exceed 3 days

>12 years old

• Instill 1-2 sprays or 1-2 gtt intranasally q4hr of 0.25-0.1% solution PRN; not to exceed 3 days

 

NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray (phenylephrine nasal) adverse (side) effects

Frequency not defined

Stinging

Dryness

Rebound congestion

Sneezing

Burning

 

Warnings

Contraindications

Cardiac disease (hypertension, HR, palpitations)

Nonselective MAO inhibitors: Risk of hypertensive reaction

 

Cautions

Rebound congestion may occur

Use caution in DM and hypertension

 

Pregnancy and lactation

Pregnancy category: C

Lactation: not known if excreted in breast milk

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray (phenylephrine nasal)

Mechanism of action

Alpha adrenergic agonist; stimulates alpha-adrenergic receptors in nasal conjunctiva and arterioles to produce vasoconstriction that results in nasal decongestion

 

Pharmacokinetics

Absorption: Minimal systemic

Duration: 2.5 - 4 hr

Onset: < 2 min