phenylephrine nasal (NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray)
Classes: Decongestants, Intranasal
- Dosing and uses of NeoSynephrine Nasal, Neo-Synephrine Cold & Sinus Mild Strength Spray (phenylephrine nasal)
- NeoSynephrine Nasal, Neo-Synephrine Cold & Sinus Mild Strength Spray (phenylephrine nasal) adverse (side) effects
- Warnings
- Pregnancy
- Pharmacology of NeoSynephrine Nasal, Neo-Synephrine Cold & Sinus Mild Strength Spray (phenylephrine nasal)
Dosing and uses of NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray (phenylephrine nasal)
Adult dosage forms and strengths
nasal spray
- 0.125%
- 0.25%
- 0.5%
- 1%
Nasal Congestion
Instill 2-3 sprays or 2-3 gtt q4hr of 0.25-0.1% solution PRN; not to exceed 3 days
Pediatric dosage forms and strengths
nasal spray
- 0.125%
- 0.25%
- 0.5%
- 1%
Nasal Congestion
<2 years
- Consult a physician
2-6 years
- 1-3 gtt intranasally q2-4hr of 0.125% solution PRN; not to exceed 3 days
6-12 years
- 2-3 gtt intranasally q4hr of 0.25% solution PRN; not to exceed 3 days
>12 years old
- Instill 1-2 sprays or 1-2 gtt intranasally q4hr of 0.25-0.1% solution PRN; not to exceed 3 days
NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray (phenylephrine nasal) adverse (side) effects
Frequency not defined
Stinging
Dryness
Rebound congestion
Sneezing
Burning
Warnings
Contraindications
Cardiac disease (hypertension, HR, palpitations)
Nonselective MAO inhibitors: Risk of hypertensive reaction
Cautions
Rebound congestion may occur
Use caution in DM and hypertension
Pregnancy and lactation
Pregnancy category: C
Lactation: not known if excreted in breast milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of NeoSynephrine Nasal, Neo-Synephrine Cold and Sinus Mild Strength Spray (phenylephrine nasal)
Mechanism of action
Alpha adrenergic agonist; stimulates alpha-adrenergic receptors in nasal conjunctiva and arterioles to produce vasoconstriction that results in nasal decongestion
Pharmacokinetics
Absorption: Minimal systemic
Duration: 2.5 - 4 hr
Onset: < 2 min