neomycin/polymyxin B/ bacitracin/pramoxine (Neosporin Plus Pain Relief Ointment, TriBiozene Ointment)
Classes: Antibacterials, Topical
- Dosing and uses of Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine)
- Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine) adverse (side) effects
- Warnings
- Pregnancy
- Pharmacology of Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine)
Dosing and uses of Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine)
Adult dosage forms and strengths
neomycin/polymyxin B/bacitracin/pramoxine
topical ointment
- (3.5mg/10,000units/500units/10mg)/g
Skin Infection Prevention
Apply small amount to cleansed wound 1-3 times/day; not to exceed 1week
Pediatric dosage forms and strengths
neomycin/polymyxin B/bacitracin/pramoxine
topical ointment
- (3.5mg/10,000units/500units/10mg)/g
Skin Infection Prevention
Apply small amount to cleansed area 1-3 times/day; not to exceed 1week
Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine) adverse (side) effects
Frequency not defined
Allergic contact dermatitis
Warnings
Contraindications
Hypersensitivity
Cautions
Ototoxicity and nephrotoxicity possible if treating large surface area or chronic use
Pregnancy and lactation
Pregnancy category: C
Lactation: unknown if neomycin, polymyxin B, or bacitracin excreted in breast milk; systemic absorption of topical lidocaine has been reported
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine)
Mechanism of action
Neomycin, polymyxin B, and bacitracin elicit bacteriostatic activity
Pramoxine provides local anesthetic effect