neomycin/polymyxin B/ bacitracin/pramoxine (Neosporin Plus Pain Relief Ointment, TriBiozene Ointment)

Dosing and uses of Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine)

• Adult
• Pediatric

 

Adult dosage forms and strengths

neomycin/polymyxin B/bacitracin/pramoxine

topical ointment

• (3.5mg/10,000units/500units/10mg)/g

 

Skin Infection Prevention

Apply small amount to cleansed wound 1-3 times/day; not to exceed 1week

 

Pediatric dosage forms and strengths

neomycin/polymyxin B/bacitracin/pramoxine

topical ointment

• (3.5mg/10,000units/500units/10mg)/g

 

Skin Infection Prevention

Apply small amount to cleansed area 1-3 times/day; not to exceed 1week

 

Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine) adverse (side) effects

Frequency not defined

Allergic contact dermatitis

 

Warnings

Contraindications

Hypersensitivity

 

Cautions

Ototoxicity and nephrotoxicity possible if treating large surface area or chronic use

 

Pregnancy and lactation

Pregnancy category: C

Lactation: unknown if neomycin, polymyxin B, or bacitracin excreted in breast milk; systemic absorption of topical lidocaine has been reported

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine)

Mechanism of action

Neomycin, polymyxin B, and bacitracin elicit bacteriostatic activity

Pramoxine provides local anesthetic effect