neomycin/polymyxin B/bacitracin topical (Neosporin Original Ointment, Triple Antibiotic Ointment)
Classes: Antibacterials, Topical
- Dosing and uses of Neosporin Original Ointment, Triple Antibiotic Ointment (neomycin/polymyxin B/bacitracin topical)
- Neosporin Original Ointment, Triple Antibiotic Ointment (neomycin/polymyxin B/bacitracin topical) adverse (side) effects
- Warnings
- Pregnancy
- Pharmacology of Neosporin Original Ointment, Triple Antibiotic Ointment (neomycin/polymyxin B/bacitracin topical)
Dosing and uses of Neosporin Original Ointment, Triple Antibiotic Ointment (neomycin/polymyxin B/bacitracin topical)
Adult dosage forms and strengths
neomycin/polymyxin B/bacitracin topicaL
topical cream/ointment
- (3.5mg/5,000units/400units)/1gram
Treatment/Prophylaxis Superficial Skin Infection
Apply topically qDay-TId
Also known as triple antibiotic cream/ointment
Pediatric dosage forms and strengths
neomycin/polymyxin B/bacitracin topicaL
topical cream/ointment
- (3.5mg/5,000units/400units)/1gram
Treatment/Prophylaxis Superficial Skin Infection
Apply topically qDay-TId
Also known as triple antibiotic cream/ointment
Neosporin Original Ointment, Triple Antibiotic Ointment (neomycin/polymyxin B/bacitracin topical) adverse (side) effects
>10%
Allergic contact dermatitis (60%)
Warnings
Contraindications
Hypersensitivity
Not for use in eyes or over large areas of body
Pregnancy and lactation
Pregnancy category: C
Lactation: unknown if distributed in breast milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Neosporin Original Ointment, Triple Antibiotic Ointment (neomycin/polymyxin B/bacitracin topical)
Mechanism of action
Neomycin: Antibiotic; inhibits production of protine in bacteria resulting in cell death
Polymyxin: Antibiotic; increases permeability of bacterial cell wall membranes resulting in cell lysis
Bacitracin: Antibiotic; bactericidal or bacteriostatic depending on concetnraiton; inhibits bacterial cell wall synthesis