Dosing and uses of Neo-Polycin (neomycin/polymyxin B/bacitracin ophthalmic)
Adult dosage forms and strengths
neomycin/polymyxin B/bacitracin ophthalmic
ophthalmic ointment
- 400 units/3.5mg/10,000 units/g
Ocular Inflammation/Infection
Apply 1/2 inch ribbon of ointment to conjunctival sac of affected eye(s) q3-4hr for 7-10 days for acute infections
Pediatric dosage forms and strengths
neomycin/polymyxin B/bacitracin ophthalmic
ophthalmic ointment
- 400 units/3.5mg/10,000 units/g
Ocular Inflammation/Infection
Apply 1/2 inch ribbon of ointment to conjunctival sac of affected eye(s) q3-4hr for 7-10 days for acute infections
Neo-Polycin (neomycin/polymyxin B/bacitracin ophthalmic) adverse (side) effects
Frequency not defined
Conjunctival edema
Rash
Allergic contact dermatitis
Itching
Failure to heaL
Swelling
Irritation
Warnings
Contraindications
Hypersensivity to neomycin, polymyxin B, zinc bacitracin
Glaucoma
Viral diseases of cornea and conjunctiva (epithelial herpes simplex keratitis, vaccinia, varicella)
Mycobacterial infection of eye & fungal diseases of ocular structures
Cautions
Contamination of container may occur, causing bacterial keratitis; avoid contamination of product
Pregnancy and lactation
Pregnancy category: C
Lacation: Excretion in breast milk unknown; caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Neo-Polycin (neomycin/polymyxin B/bacitracin ophthalmic)
Mechanism of action
Bacitracin: Inhibits bacterial cell wall synthesis by preventing the incorporation of amino acids and nucleotides into the cell walL
Neomycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits
Polymyxin B: Bactericidal; causes leakage of bacterial membrane
