Dosing and uses of Nauzene (sodium citrate/dextrose/fructose)
Adult dosage forms and strengths
sodium citrate/dextrose/fructose
tablet, chewable
- 230mg/968mg/175mg
oral solution
- (0.921g/4.35g/4.17g)/15mL
Nausea
Indicated for relief of nausea associated with upset stomach, including that due to overindulgence in food and drink
Chew 2-4 tablets completely; may repeat after 15 minutes if needed
Not to exceed 6 doses/24 hr
Pediatric dosage forms and strengths
<18 years: Safety and efficacy not established
Warnings
Contraindications
Hereditary fructose intolerance
Cautions
Phenylketonurics; contains phenylalanine 4.5 mg/tablet
Diabetes; product contains sugar
Antacids may alter gastric pH and interfere with absorption of some concurrent medications
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown whether distributed in breast milk
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Nauzene (sodium citrate/dextrose/fructose)
Mechanism of action
Citric acid: Antacid; forms sodium citrate which neutralizes stomach acid
Dextrose and fructose: Hyperosmolar carbohydrate solutions have a direct effect on the GI tract wall, resulting in reduced GI smooth muscle contraction
