Dosing and uses of Natroba (spinosad)
Adult dosage forms and strengths
suspension, topicaL
- 0.9%
Lice
Apply suspension to dry scalp and hair using only the amount needed to cover the scalp and hair, after 10 minutes, rinse off with warm water
May repeat if live lice are seen 7 days after first treatment
Administration
Does not require combing and nit removaL
For topical use only
Shake bottle well before application
Pediatric dosage forms and strengths
suspension, topicaL
- 0.9%
Lice
<6 months
- Do not use
- See benzyl alcohol warning in neonates and infants
≥6 months
- Apply suspension to dry scalp and hair using only the amount needed to cover the scalp and hair, after 10 minutes, rinse off with warm water
- May repeat if live lice are seen 7 days after first treatment
Administration
Does not require combing and nit removaL
For topical use only
Shake bottle well before application
Natroba (spinosad) adverse (side) effects
1-10%
Application site erythema (3%)
Ocular erythema (2%)
Ocular hyperemia (2%)
Application site irritation (1%)
<1%
Application site dryness
Application site exfoliation
Alopecia
Dry skin
Warnings
Contraindications
Hypersensitivity
Cautions
Contains benzyl alcohol; toxicity and deaths reported in neonates and infants below the age of 6 months with systemic exposure to benzyl alcohol (ie, neonatal gasping syndrome)
Pregnancy and lactation
Pregnancy category: B; low systemic exposure
Lactation: Active ingredient (spinosad) is not distributed in breast milk; however, caution advised because the benzyl alcohol component may be systemically absorbed; lactating women may choose to pump and discard breast milk for 8 hr (5 half-lives of benzyl alcohol) following application
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Natroba (spinosad)
Mechanism of action
Causes neuronal excitation in insects, followed by hyperexcitation, paralysis, and death
Pharmacokinetics
Absorption: Not absorbed topically
