cromolyn sodium, intranasal (NasalCrom)
Classes: Allergy, Intranasal; Mast Cell Stabilizers, Intranasal
Dosing and uses of NasalCrom (cromolyn sodium intranasal)
Adult dosage forms and strengths
intranasal spray
- 5.2mg/spray
Allergic Rhinitis
1 spray each nostril q6-8hr, may increase to 6 times/day; may take 2-4 weeks before symptomatic relief observed
For best results, initiate 1-2 weeks before contact with allergens
Pediatric dosage forms and strengths
intranasal spray
- 5.2mg/spray
Allergic Rhinitis
<2 years: Safety and efficacy not established
≥2 years: 1 spray each nostril q6-8hr, may increase to 6 times/day; may take 2-4 weeks before symptomatic relief observed
For best results, initiate 1-2 weeks before contact with allergens
NasalCrom (cromolyn sodium intranasal) adverse (side) effects
Frequency not defined
Transient nasal stinging or sneezing after administration
Headache
Unpleasant taste
Hoarseness (cough)
Epistaxis
Warnings
Contraindications
Hypersensitivity
Cautions
No benefit in acute setting
Symptoms may reoccur while tapering the dose
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown whether distributed in breast milk, caution advised
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of NasalCrom (cromolyn sodium intranasal)
Mechanism of action
Mast cell stabilizer
Pharmacokinetics
Onset of action: 1-2 weeks
Half-life elimination: 80-90 min
Excretion: Urine and feces
