cromolyn sodium, intranasal (NasalCrom)

Dosing and uses of NasalCrom (cromolyn sodium intranasal)

• Adult
• Pediatric

 

Adult dosage forms and strengths

intranasal spray

• 5.2mg/spray

 

Allergic Rhinitis

1 spray each nostril q6-8hr, may increase to 6 times/day; may take 2-4 weeks before symptomatic relief observed

For best results, initiate 1-2 weeks before contact with allergens

 

Pediatric dosage forms and strengths

intranasal spray

• 5.2mg/spray

 

Allergic Rhinitis

<2 years: Safety and efficacy not established

≥2 years: 1 spray each nostril q6-8hr, may increase to 6 times/day; may take 2-4 weeks before symptomatic relief observed

For best results, initiate 1-2 weeks before contact with allergens

 

NasalCrom (cromolyn sodium intranasal) adverse (side) effects

Frequency not defined

Transient nasal stinging or sneezing after administration

Headache

Unpleasant taste

Hoarseness (cough)

Epistaxis

 

Warnings

Contraindications

Hypersensitivity

 

Cautions

No benefit in acute setting

Symptoms may reoccur while tapering the dose

 

Pregnancy and lactation

Pregnancy category: C

Lactation: Unknown whether distributed in breast milk, caution advised

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of NasalCrom (cromolyn sodium intranasal)

Mechanism of action

Mast cell stabilizer

 

Pharmacokinetics

Onset of action: 1-2 weeks

Half-life elimination: 80-90 min

Excretion: Urine and feces