Dosing and uses of Mydriacyl, Tropicacyl (tropicamide)
Adult dosage forms and strengths
ophthalmic solution
- 0.5%
- 1%
Refraction (Mydriasis)
1-2 gtt of 1% solution in eye(s), repeat in 5 min, perform exam within 30 min of second instillation
Funduscopic Exam (Cycloplegia)
1-2 gtt of 0.5% solution in eyes 15-20 min before exam, may repeat q30minutes PRn
Pediatric dosage forms and strengths
ophthalmic solution
- 0.5%
- 1%
Refraction (Mydriasis)
As adult; 1-2 gtt of 1% solution in eye(s), repeat in 5 min, perform exam within 30 min of second instillation
Funduscopic Exam (Cycloplegia)
As adult; 1-2 gtt of 0.5% solution in eyes 15-20 min before exam, may repeat q30minutes PRn
Mydriacyl, Tropicacyl (tropicamide) adverse (side) effects
Frequency Not Ddefined
Increased IOp
Transient stinging
Dry mouth
Blurred vision
Photophobia with or without corneal staining
Tachycardia
Headache
Parasympathetic stimulation
Allergic reactions
Warnings
Contraindications
Hypersensitivity
Known or suspected angle-closure glaucoma, presence of a shallow anterior chamber unless gonioscopic observation of the chamber angle is possible
Cautions
Hypertension, hyperthyroidism, diabetes mellitus, cardiac disorders
Remove contact lenses before instilling drops
Possibility of undiagnosed glaucoma should be considered
Risk of potentially dangerous CNS disturbances in Peds
May cause increased IOp
0.5% solution incapable of producing satisfactory cycloplegia
Pregnancy and lactation
Pregnancy category: C
Lactation: not known if distributed in milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Mydriacyl, Tropicacyl (tropicamide)
Peak: 20-40 min (mydriasis), 20-35 min (cycloplegia)
Recovery: 6 hr
Mechanism of action
Blocks acetylcholine resulting in relaxation of cholinergically innervated iris sphincter muscle
Adrenergic innervation to radial muscle is therefore unopposed and pupil becomes dilated
