Dosing and uses of Moduretic (amiloride-hydrochlorothiazide)
Adult dosage forms and strengths
amiloride/hydrochlorothiazide
tablet
- 5mg/50mg
Hypertension
5-10 mg/50-100 mg (amiloride/HCTZ)/day PO
Pediatric dosage forms and strengths
Safety & efficacy not established
Moduretic (amiloride-hydrochlorothiazide) adverse (side) effects
1-10%
Amiloride
- Hyperkalemia (10%)
- Anorexia (3-8%)
- Diarrhea (3-8%)
- Headache (3-8%)
- Nausea (3-8%)
- Vomiting (3-8%)
- Abdominal pain (<3%)
- Appetite changes (<3%), Constipation (<3%), Cough (<3%), Dizziness (<3%), Dyspnea (<3%), Encephalopathy (<3%), Fatigue (<3%), Gas pain (<3%), Impotence (<3%), Muscle cramps (<3%), Weakness (<3%)
Hydrochlorothiazide
- Hypotension
- Anorexia
- Epigastric distress
- Hypokalemia
- Phototoxicity
Warnings
Contraindications
Hypersensitivity to amiloride, HCTZ or sulfonamides
Acute renal failure
Acute/severe hepatic failure
Anuria
Hyperkalemia
Pregnancy and lactation
Pregnancy category: B
Lactation: Excretion in breast milk is unknown. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
