Dosing and uses of MnCl2 (manganese)
Adult dosage forms and strengths
tablet
- 10mg (elemental)
- 15mg (elemental)
- 93mg (aspartate; 25mg elemental)
- 50mg (gluconate; 5.7mg elemental)
capsule
- 16.67mg
injectable solution
- 0.1mg/mL
Adequate Intake
Male: 1.9-2.3 mg/day
Female: 1.6-1.8 mg/day
Pregnancy: 2 mg/day
Lactation: 2.6 mg/day
Prevention of Deficiency
Parenteral solution (TPN):150-800 mcg/day IV
Osteoporosis (Off-label)
5 mg PO qDay
Pediatric dosage forms and strengths
injectable solution: MnCl2
- 0.1mg/mL
Adequate Intake
<6 months: 0.3-0.6 mg/day
6-12 months: 0.6-1.0 mg/day
1-3 years: 1.0-1.5 mg/day
3-8 years: 1.5-2.0 mg/day
8-13 years: 1.9 mg/day (males); 1.6 mg/day (females)
13-18 years: 2.2 mg/day (males); 1.6 mg/day (females)
Prevention of Deficiency
Parenteral solution (TPN): 2-10 mcg/kg/day IV
MnCl2 (manganese) adverse (side) effects
Not well documented
Warnings
Contraindications
Direct IV/IM injection administration (must dilute)
Cautions
May cause tissue damage if administered IV or IM directly due to very acidic solution (pH 2.0)
Injection contains aluminum; use caution in renal impairment and premature infants
Use caution in liver/biliary tract dysfunction, renal impairment (may need to decrease or withhold dose)
Pregnancy and lactation
Pregnancy category: inj: C
Lactation: Use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Nutrition
Sources
Pineapples, almonds, oatmeal, chocolate, pumpkin seeds, whole wheat pasta, pecans, spinach
Pharmacology of MnCl2 (manganese)
Mechanism of action
Cofactor in many enzymes, incl superoxide dismutase (SOD, an antioxidant)
Necessary for glycemic control, energy metabolism, thyroid hormone function
May enhance bone turnover, cartilage synthesis
Pharmacokinetics
Absorption: Poor
Distribution: Mitochondria of kidney, liver, pituitary gland, and bone
Excretion: Bile (primarily); urine (negligible)
Administration
IV Info
Dilute in at least 100 mL (do NOT use undiluted)
Use promptly after mixing & in a single operation
No preservatives-discard unused portion
