Dosing and uses of Metastron (strontium 89 chloride)
Adult dosage forms and strengths
injectable solution
- 1 MCi/mL
Bone Metastasis, Pain from Metastases
148 MBq (=4 mCi) slow IV injection Or
1.5-2.2 MBq/kg (= 40-60 uCi/kg)
Repeat doses not recommended more frequently than 90 days intervaL
Pediatric dosage forms and strengths
Safety and efficacy not established
Metastron (strontium 89 chloride) adverse (side) effects
Frequency not defined
Bone marrow toxicity
Renal impairment
Flushing after rapid injection
Hot flush
Transient increase in bone pain
Chills/fever
Septicemia
Thrombocytopenia
Warnings
Contraindications
Hypersensitivity
Cautions
Platelet < 60,000/mm³; WBC < 2400/mm³
Pain relief may take 7-20 days after injection
Only for cancers involving bone
Bone marrow toxicity may occur
Evaluate risk/benefits in patients with renal impairment (excreted renally)
Nor for use in patients with cancer not involving bone or short life expectancy
Incontinent patients may require urinary catherization to reduce radioactive contamination
Use only under the supervision of experienced personneL
Pregnancy and lactation
Pregnancy category: d
Lactation: excreted in breast milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Metastron (strontium 89 chloride)
Mechanism of action
Emits beta radiationthat is taken up by primary bone and metastatic bone lesions, Reduces pain
Pharmacokinetics
Half-Life: 50.5 days
Duration: 6-12 months
Onset: 7-20 days
Excretion: urine (2/3) & feces (1/3)
Administration
IV Administration
Slow IV over 1-2 min
Storage
Store inside transportation container
Expires 28 days after calibration (dates stated on label)
