Suggested dosing of Mega taurine (taurine)
Congestive Heart Failure
2-6 g/day PO div BID-TId
Acute Hepatitis
4 g PO TID x 6 weeks
Treatment of Steatorrhea in Children with Cystic Fibrosis
30 mg/kg day x 4 months in addition to pancreatic enzyme supplementation
Cystathionine Beta-Synthase Deficient Homocystinuria (Orphan)
Indicated for treatment of cystathionine beta-synthase deficient homocystinuria
Orphan indication sponsor
- Johan L. Van Hove, MD, PhD; Department of Pediatrics/University of Colorado DE; 13121 E. 17th Ave; PO Box 6508; Aurora, CO 80045
Suggested uses of Mega taurine (taurine)
CHF, hypertension, hypercholesterolemia, cystic fibrosis, antiatherogenic effects
Other uses include seizure disorders (epilepsy), autism, ADHD, retinal degeneration, diabetes, alcoholism, improve mental performance & antioxidant.
Efficacy
In human clinical studies taurine lowered blood pressure
CHF: Seems to improve left ventricular function in patients with New York Heart Association functional class II to IV
Acute Hepatitis: Might improve liver function
In animal studies taurine lowered lipid levels, but human studies are contradictory
Mega taurine (taurine) adverse (side) effects
None reported
Warnings
Contraindications
Hypersensitivity
Cautions
Pregnancy, lactation
Monitor pts with CHF
Pregnancy and lactation
Pregnancy category: avoid use
Lactation: avoid use
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Mega taurine (taurine)
Metabolism: liver
Excretion: feces & urine
Mechanism of action
Antioxidant, putative hypocholesterolemic, hypotensive, antiatherogenic & detoxifying activities
May also have steatorrhea-reducing activity in pts with cystic fibrosis & putative antidiabetic, inotropic & antiseizure activities
