Dosing and uses of Marezine, Bonine for Kids (cyclizine)
Adult dosage forms and strengths
tablet
- 25mg
- 50mg
Motion Sickness
Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness
50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day
Pediatric dosage forms and strengths
tablet
- 25mg
- 50mg
tablet, chewable
- 25mg
Motion Sickness
Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness
6-12 years: 25 mg PO up to 3 times/day; not to exceed 75 mg/day
>12 years: 50 mg PO taken 30 minutes before departure, may repeat in 4-6 hr if needed, up to 200 mg/day
Geriatric dosage forms and strengths
Use lowest dose in divided doses in the elderly because of potential anticholinergic effects
May cause confusion or aggravate symptoms of confusion in those with dementia; limit use if possible in the elderly
Constipation and difficulty voiding urine may occur in the elderly
Motion Sickness
Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness
50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day
Marezine, Bonine for Kids (cyclizine) adverse (side) effects
>10%
Drowsiness
Xerostomia
1-10%
Headache
Dermatitis
Nausea
Urinary retention
Diplopia
Polyuria
Warnings
Contraindications
Hypersensitivity
Do not use in patients with asthma, glaucoma, emphysema, chronic pulmonary disease, shortness of breath, difficulty in breathing or difficulty in urination due to enlargement of the prostate gland unless directed by a doctor
Cyclizine should not be used concurrently with sedatives, tranquilizers, or anticholinergic medications
Cautions
May have hypotensive effects, which may be confusing or dangerous in postoperative patients
May produce drowsiness; caution while driving or performing other tasks requiring alertness
Pregnancy and lactation
Pregnancy category: B
Lactation: unknown
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Marezine, Bonine for Kids (cyclizine)
Mechanism of action
Cyclizine is a piperazine derivative that has antiemetic, anticholinergic, and antihistaminic properties; reduces the sensitivity of the labyrinthine apparatus and has central actions on the chemoreceptor trigger zone
Pharmacokinetics
Onset: 30 to 60 minutes, depending on dose
Duration: 4 to 6 hr
Metabolism: Hepatic
Half-life elimination: 14 hr (cyclizine); 24hr (norcyclizine)
Excretion: Urine (<1% unchanged)
Vd: 17 L/kg
