Dosing and uses of Magaldrate (Riopan)
Adult dosage forms and strengths
oral suspension
- 540mg/5mL
oral suspension: magaldrate-simethicone
- 540mg - 40mg/5mL
Heartburn, Sour Stomach, & Acid Indigestion
5-10 mL (1-2 teaspoonfuls; 540-1080 mg) between meals and HS; not to exceed 80 mL (16 teaspoonfuls) in 24-hour period
Other Indications & Uses
Hyperphosphatemia, Mg deficiency
Off-label: Gastric & duodenal ulcer, GERd
Neutralizes gastric acid, increases gastric pH
Pediatric dosage forms and strengths
Heartburn, Sour Stomach, & Acid Indigestion
Safety & efficacy not established
Magaldrate (Riopan) adverse (side) effects
>10%
Aluminum oxide
- Chalky taste
- Constipation
- Fecal impaction
- Stomach cramps
Frequency not defined
Aluminum oxide
- Nausea
- Vomiting
- Aluminum intoxication
- Hypophosphatemia
- Osteomalacia
Magnesium oxide
- Diarrhea
- Hypermagnesemia
Warnings
Contraindications
Hypersensitivity to any component
Cautions
Renal failure, Mg-restricted diet
May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug
Pregnancy and lactation
Pregnancy category: Magaldrate: ?; simethicone: C
Lactation: not known whether aluminum oxide or magnesium oxide is excreted in breast milk, use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Magaldrate (Riopan)
Duration:
For antacid action, dependent on gastric emptying time:
- Fasting state: 20-60 min
- 1hr after meals: up to 3 hr on the fasting
Excretion:
Aluminium oxide: absorbed Al ions are eliminated in the urine (0.1-0.5 mg of Al in aluminium-containing antacid is absorbed from standard daily doses of antacid), insoluble or poorly absorbed Al salts in the intestines are excreted in the feces
Magnesium oxide: absorbed Mg ions (up to 30%) are eliminated in urine, unabsorbed drug is excreted in feces
