clotrimazole topical (Gyne Lotrimin, Lotrimin, Lotrimin AF, Mycelex topical)

Dosing and uses of Gyne Lotrimin, Lotrimin (clotrimazole topical)

• Adult
• Pediatric

 

Adult dosage forms and strengths

cream/ointment/topical solution

• 1%

 

Cutaneous Candidiasis/ Dermatophytosis

OTC products indicated for treatment of tinea pedis, tinea cruris, and tinea corporus

Prescription products indicated for Candida albicans and tinea versicolor, in addition to OTC product indications

Apply to affected area q12hr

See also combo with betamethasone (Lotriderm/Lotrisone)

 

Pediatric dosage forms and strengths

cream/ointment/topical solution

• 1%

 

Tinea Corporis/Tinea Pedis

Apply to affected area q12hr for 4 weeks

 

Tinea Cruris

>2 years: Apply to affected area q12hr for 2 weeks

 

Candidiasis

Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks

 

Tinea Versicolor

Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks

 

Gyne Lotrimin, Lotrimin (clotrimazole topical) adverse (side) effects

Frequency not defined

Blistering

Erythema

Edema

Pruritus

Burning

Stinging

Peeling

Urticaria

Skin fissures

General irritation of the skin

Elevated serum AST (SGOT) concentrations (15%)

 

Warnings

Contraindications

Hypersensitivity to clotrimazole

 

Cautions

Avoid contact with eyes

 

Pregnancy and lactation

Pregnancy category B during 2nd and 3rd trimester; safety in 1st trimester not established

Lactation: Excretion in milk unknown; use with caution

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Gyne Lotrimin, Lotrimin (clotrimazole topical)

Mechanism of action

Antifungal activity

Alters cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane, causing essential intracellular elements to leak

 

Absorption

Minimal through skin