clotrimazole topical (Gyne Lotrimin, Lotrimin, Lotrimin AF, Mycelex topical)
Classes: Antifungals, Topical
Dosing and uses of Gyne Lotrimin, Lotrimin (clotrimazole topical)
Adult dosage forms and strengths
cream/ointment/topical solution
- 1%
Cutaneous Candidiasis/ Dermatophytosis
OTC products indicated for treatment of tinea pedis, tinea cruris, and tinea corporus
Prescription products indicated for Candida albicans and tinea versicolor, in addition to OTC product indications
Apply to affected area q12hr
See also combo with betamethasone (Lotriderm/Lotrisone)
Pediatric dosage forms and strengths
cream/ointment/topical solution
- 1%
Tinea Corporis/Tinea Pedis
Apply to affected area q12hr for 4 weeks
Tinea Cruris
>2 years: Apply to affected area q12hr for 2 weeks
Candidiasis
Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks
Tinea Versicolor
Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks
Gyne Lotrimin, Lotrimin (clotrimazole topical) adverse (side) effects
Frequency not defined
Blistering
Erythema
Edema
Pruritus
Burning
Stinging
Peeling
Urticaria
Skin fissures
General irritation of the skin
Elevated serum AST (SGOT) concentrations (15%)
Warnings
Contraindications
Hypersensitivity to clotrimazole
Cautions
Avoid contact with eyes
Pregnancy and lactation
Pregnancy category B during 2nd and 3rd trimester; safety in 1st trimester not established
Lactation: Excretion in milk unknown; use with caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Gyne Lotrimin, Lotrimin (clotrimazole topical)
Mechanism of action
Antifungal activity
Alters cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane, causing essential intracellular elements to leak
Absorption
Minimal through skin
