Dosing and uses of Lacrisert (hydroxypropyl cellulose ophthalmic)
Adult dosage forms and strengths
ophthalmic insert
- 5mg/insert
Dry Eye Syndrome
Indicated for moderate-to-severe dry eye syndromes, including keratoconjunctivitis sicca
Using supplied applicator, place 1 ophthalmic insert in each eye qDay; some patients may require twice daily dosing
Optimal results may not be observed for several weeks
Pediatric dosage forms and strengths
Safety and efficacy not established
Lacrisert (hydroxypropyl cellulose ophthalmic) adverse (side) effects
Frequency not defined
Transient blurred vision
Ocular discomfort or irritation
Matting or stickiness of eyelashes
Photophobia
Hypersensitivity
Edema of the eyelids
Hyperemia
Warnings
Contraindications
Hypersensitivity
Cautions
Carefully follow instructions for inserting and removing
Improper placement may cause corneal abrasion
Transient blurred vision common after insertion, caution when operating hazardous machinery or driving
May be inadvertently expelled from the eye, especially in patients with shallow conjunctival fornices
Avoid rubbing the eye(s) containing insert, especially upon awakening, so as not to dislodge or expel the insert; if required, another insert may be administered
Not for use in conjunction with hot laser treatment
If solution dries on optical surfaces, let them stand in cool water before cleansing
Pregnancy and lactation
Pregnancy category: A
Lactation: Unlikely to be distributed in breast milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Lacrisert (hydroxypropyl cellulose ophthalmic)
Mechanism of action
Ocular lubricant
Administration
Instructions
Using applicator supplied in package, place insert into inferior cul-de-sac of the eye beneath the base of the tarsus (not in apposition to the cornea, nor beneath the eyelid at the level of the tarsal plate)
If not properly positioned, it will be expelled into the interpalpebral fissure, and may cause symptoms of a foreign body
