sulfacetamide topical (Klaron, Ovace Plus, Ovace Plus Shampoo, Ovace Plus Wash, Ovace Wash)
Classes: Acne Agents, Topical; Sulfonamides, Topical
Dosing and uses of Klaron, Ovace Plus (sulfacetamide topical)
Adult dosage forms and strengths
lotion
- 10% (Klaron)
cream
- 10% (Ovace Plus)
shampoo
- 10% (Ovace Plus Shampoo)
wash, oil in water emulsion
- 10% (Ovace Plus Wash)
wash
- 10% (Ovace Wash)
Acne Vulgaris
Klaron: Apply thin film topically to affected areas BId
Seborrheic Dermatitis
Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides
Ovace Plus Cream: Apply to affeted areas BID x8-10 days
Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days
For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence
Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week
Administration
Avoid contact with eyes or mucous membranes
Pediatric dosage forms and strengths
lotion
- 10% (Klaron)
cream
- 10% (Ovace Plus)
shampoo
- 10% (Ovace Plus Shampoo)
wash, oil in water emulsion
- 10% (Ovace Plus Wash)
wash
- 10% (Ovace Wash)
Acne Vulgaris
<12 years: Safety and efficacy not established
Klaron ≥12 years: Apply thin film topically to affected areas BId
Seborrheic Dermatitis
Indicated for scaling dermatoses (eg, seborrheic dermatitis, seborrhea sicca [dandruff]); also indicated for the treatment of secondary bacterial infections of the skin due to organisms susceptible to sulfonamides
<12 years: Safety and efficacy not established
≥12 years
- Ovace Plus Cream: Apply to affeted areas BID x8-10 days
- Ovace Wash, Ovace Plus Wash: Wash affected areas BID x 8-10 days
- For cream or wash, as condition subsides, lengthen interval between applications to once or twice weekly or every other week to prevent recurrence
- Ovace Plus Shampoo: Apply to wet hair and massage vigorously into scalp; rinse thoroughly; use at least twice/week
Administration
Avoid contact with eyes or mucous membranes
Klaron, Ovace Plus (sulfacetamide topical) adverse (side) effects
1-10%
Erythema
Itching
Edema
Local irritation
Stinging
Burning
Warnings
Contraindications
Hypersensitivity
Cautions
Avoid contact with eyes or mucous membranes
Severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias reported
Avoid UV exposure
Contains sodium metabisulfite that is known to cause allergic reactions
Pregnancy and lactation
Pregnancy category: C
Lactation: not known whether excreted in breast milk, use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Klaron, Ovace Plus (sulfacetamide topical)
Mechanism of action
Para-aminobenzoic acid (PABA) inhibitor; restricts folic acid synthesis required for bacterial growth
Absorption
4%