Dosing and uses of Kerydin (tavaborole)
Adult dosage forms and strengths
solution
- 43.5mg/mL (0.5%)
Onychomycosis of the Toenail
Indicated for onychomycosis of the toenail(s) due to Trichophyton rubrum or Trichophyton mentagrophytes
Clean and dry nails prior to use; apply to completely cover nail surface and under tip of each nail being treated; allow solution to dry following application
Apply to affected toenails qDay for 48 weeks
Pediatric dosage forms and strengths
Safety and efficacy not established
Kerydin (tavaborole) adverse (side) effects
1-10%
Application site exfoliation (2.7%)
Ingrown toenail (2.5%)
Application site erythema (1.6%)
Application site dermatitis (1.3%)
Warnings
Contraindications
None reported by manufacturer
Cautions
Not for oral, ophthalmic, or intravaginal use
Avoid contact with eyes, mouth, vagina, or skin immediately surrounding treated nail; wipe away excess solution from surrounding skin
Product is flammable; avoid use near heat or open flame
Pregnancy and lactation
Pregnancy category: C
Use during pregnancy only if benefits outweigh risks
Lactation: Unknown if distributed in human breast milk; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Kerydin (tavaborole)
Mechanism of action
An oxaborole antifungal (boron-containing compound); inhibits protein synthesis by inhibition of an aminoacyl-transfer ribonucleic acid (tRNA) synthetase (AARS)
Elimination
Excretion: Urine (primarily)
