pramoxine topical (Itch-X Gel, Itch-X Spray, PrameGel, Prax, Sarna Sensitive Anti-Itch, proctoFoam, Azo Itch Relief Maximum Strength Analgesic Cream, Eczemin)
Classes: Anesthetics, Topical; Antipruritics/Non-corticosteroid Topical
Dosing and uses of Itch-X Gel, Itch-X Spray (pramoxine topical)
Adult dosage forms and strengths
topical cream
- 1%
topical geL
- 1%
topical lotion
- 1%
topical spray
- 1%
Topical Pain
Apply to affected area up to 3-4 times/day
Feminine Itching
Apply small amount to external vaginal area up to 4 times/day
Pediatric dosage forms and strengths
topical cream
- 1%
topical geL
- 1%
topical lotion
- 1%
topical spray
- 1%
Topical Pain
<2 years: Safety and efficacy not established
>2 years: Apply to affected area up to 3-4 times/day
Itch-X Gel, Itch-X Spray (pramoxine topical) adverse (side) effects
Frequency not defined
Irritation
Pruritus
Contact dermatitis
Warnings
Contraindications
Hypersensitivity
Cautions
Do not exceed daily recommended dosage
Do not use in eyes or nose
Do not apply to large areas of body
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown if excreted in breast milk; exercise caution
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Itch-X Gel, Itch-X Spray (pramoxine topical)
Mechanism of action
Local anesthetic; stabilizes neuronal membranes and prevent generation/conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold
Absorption
Onset: 32-5 min