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pramoxine topical (Itch-X Gel, Itch-X Spray, PrameGel, Prax, Sarna Sensitive Anti-Itch, proctoFoam, Azo Itch Relief Maximum Strength Analgesic Cream, Eczemin): Dosing and Uses

 

Classes: Anesthetics, Topical; Antipruritics/Non-corticosteroid Topical

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dosing and uses of Itch-X Gel, Itch-X Spray (pramoxine topical)

 

Adult dosage forms and strengths

topical cream

  • 1%

topical geL

  • 1%

topical lotion

  • 1%

topical spray

  • 1%

 

Topical Pain

Apply to affected area up to 3-4 times/day

 

Feminine Itching

Apply small amount to external vaginal area up to 4 times/day

 

Pediatric dosage forms and strengths

topical cream

  • 1%

topical geL

  • 1%

topical lotion

  • 1%

topical spray

  • 1%

 

Topical Pain

<2 years: Safety and efficacy not established

>2 years: Apply to affected area up to 3-4 times/day

 

Itch-X Gel, Itch-X Spray (pramoxine topical) adverse (side) effects

Frequency not defined

Irritation

Pruritus

Contact dermatitis

 

Warnings

Contraindications

Hypersensitivity

 

Cautions

Do not exceed daily recommended dosage

Do not use in eyes or nose

Do not apply to large areas of body

 

Pregnancy and lactation

Pregnancy category: C

Lactation: Unknown if excreted in breast milk; exercise caution

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Itch-X Gel, Itch-X Spray (pramoxine topical)

Mechanism of action

Local anesthetic; stabilizes neuronal membranes and prevent generation/conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold

 

Absorption

Onset: 32-5 min