Dosing and uses of Isovue, Scanlux (iopamidol)
Adult dosage forms and strengths
Content expressed as organic bound iodine/mL
injectable solution
- 200mg/mL (41%)
- 300mg/mL (61%)
intravenous solution
- 200mg/mL (41%)
- 250mg/mL (51%)
- 300mg/mL (61%)
- 370mg/mL (76%)
Angiography
Cerebral Arteriography
- 300 mg/mL: 8-12 mL intra-arterial, may repeat, not to exceed 90 mL
Peripheral Venography
- 200 mg/mL: 25-150 mL IV per lower extremity; total not to exceed 350 mL
Coronary Arteriography
- 370 mg/mL: 2-10 mL IV; monitor EKG; not to exceed 200 mL
Coronary Ventriculography
- 370 mg/mL: 25-50 mL IV; monitor EKG; not to exceed 200 mL
Selective Visceral Arteriography
- 370 mg/mL: Up to 50 mL IV; not to exceed 225 mL
Selective Visceral Aortography
- 370 mg/mL: Up to 50 mL IV; not to exceed 225 mL
Peripheral Venography
- 200 mg/mL: 25-150 mL; not to exceed 350 mL
Computed Tomography
CECT of the Head
- 250 mg/mL: 130-240 mL IV; not to exceed 240 mL
- Alternatively, 300 mg/mL: 100-200 mL IV; not to exceed 200 mL
- Imaging may be done immediately after completing administration
CECT of the Body
- 250 mg/mL: 130-240 mL IV; not to exceed 240 mL
- Alternatively, 300 mg/mL: 100-200 mL IV; not to exceed 200 mL
- Imaging may be done immediately after completing administration
Urography
Excretory Urography
- 250 mg/mL: 50-100 mL IV OR
- 300 mg/mL: 50 mL IV OR
- 370 mg/mL: 40 mL IV
Pediatric dosage forms and strengths
Content expressed as iodine/mL
injectable solution
- 200mg/mL (41%)
- 300mg/mL (61%)
intravenous solution
- 200mg/mL (41%)
- 250mg/mL (51%)
- 300mg/mL (61%)
- 370mg/mL (76%)
Angiocardiography
For 370 mg/mL:
<2 years: 10-15 mL IV, not to exceed 40 mL totaL
2-9 years: 15-30 mL IV, not to exceed 50 mL (2-4 years) or 100 mL (5-9 years)
10-18 years: 20-50 mL IV, not to exceed 125 mL
Computed Tomography
CECT of the Head
- 250 mg/mL: 1.2-3.6 mL/kg IV; not to exceed 30 g of iodine
- Alternatively, 300 mg/mL: 1-3 mL/kg IV; not to exceed 30 g of iodine
CECT of the Body
- 250 mg/mL: 1.2-3.6 mL/kg IV; not to exceed 30 g of iodine OR
- 300 mg/mL: 1-3 mL/kg IV; not to exceed 30 g of iodine
Urography
Excretory Urography
- 250 mg/mL: 1.2-3.6 mL/kg IV; not to exceed 30 g of iodine OR
- 300 mg/mL: 1-3 mL/kg IV; not to exceed 30 g of iodine
Warnings
Black box warnings
Not for intrathecal use
Contraindications
Hypersensitvity to product or components
Intrathecal injection concurrently with intrathecal corticosteroid administration (significant bacterial infection)
Cautions
Before examination patients should be well hydrated to prevent contrast associated nephropathy
Caution in patients with seizures, thromboembolic diseases including IM and stroke, chronic alcoholism, heart failure, hepatorenal insufficiency, hyperthyroidism, multiple myeloma, pheochromocytoma, renal disease, sickle cell disease
Serious adverse events reported from inadvertent intrathecal administration of iodinated contrast that is not indicated for intrathecal use (Isovue and Isovue Miltipack are not for intrathecal administration)
Pregnancy and lactation
Pregnancy category: B
Lactation: Excretion into breast milk unknown; not recommended
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Isovue, Scanlux (iopamidol)
Mechanism of action
Radiographic visualization achieved through the opacification of vessels and anatomical structures in the path of flow of the contrast media
Pharmacokinetics
Half-life: 2 hr; prolonged in renal impairment
Excretion: Urine (80-90%)
