Dosing and uses of Hyper Tet, HyperTET S/D (tetanus immune globulin (TIG))
Adult dosage forms and strengths
powder for injection
- 250 units
Tetanus
Prophylaxis: 250 Units IM (single dose)
Active tetanus: 3000-6000 Units
Clean minor wound
- # doses unknown or 0-2 doses; toxoid only
- >3 doses; toxoid if >10 years ago
All other wounds
- # doses unknown or 0-1 doses; toxoid plus IG
- 2 doses; toxoid, but no IG if wound <24 hours old
- >3 doses; toxoid if >5 years ago, and no IG
Other Indications & Uses
Postexposure prophylaxis
Pediatric dosage forms and strengths
powder for injection
- 250 units
Tetanus
>7 years old: 250 Units IM (single dose)
<7 years old: 4 Unit/kg or 250 Units Im
Hyper Tet, HyperTET S/D (tetanus immune globulin (TIG)) adverse (side) effects
Frequency not defined
Urticaria
Injection site pain
N/V
Fever
Lethargy
Chest tightness
Anaphylaxis
Angioneurotic edema
Nephrotic syndrome (rare)
Warnings
Contraindications
Hypersensitivity to gamma globulin, IgA, thimerosaL
Cautions
Thrombocytopenia or coagulation disorders that contraindicate IM inj
Made from human plasma, small risk of viral transmission through admin
Pregnancy and lactation
Pregnancy category: C
Lactation: not known if excreted in breast milk, no adverse effects reported
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Hyper Tet, HyperTET S/D (tetanus immune globulin (TIG))
Half-Life: 28 d
Mechanism of action
Human immune globulins from donors
