Dosing and uses of Hetrazan (diethylcarbamazine)
Adult dosage forms and strengths
Available from the CDC
tablet
- 50mg
- 200mg
- 400mg
W. Bancrofti, B Malayi
Day 1: 50 mg PO PC
Day 2: 50 mg TId
Day 3: 100 mg TId
Day 4-14: 6 mg/kg/day divided TId
Loa Loa
Day 1: 50 mg PO PC
Day 2: 50 mg TId
Day 3: 100 mg TId
Day 4-21: 9 mg/kg/day divided TId
M. Streptocerca
6 mg/kg PO qDay x14 days
Pulmonary Eosinophilia, Tropical
Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days
Larva Migrans, Visceral
6 mg/kg/day divided TID x7-10 days
Other Information
Available from Wyeth-Ayerst for compassionate use only: (610)688-4400 or from CDC via compassionate INd
Pediatric dosage forms and strengths
Available from the CDC
tablet
- 50mg
- 200mg
- 400mg
W. Bancrofti, B Malayi
Day 1: 1 mg/kg PO PC
Day 2: 1 mg/kg PO TId
Day 3: 1-2 mg/kg PO TId
Day 4-14: 6 mg/kg/day divided TId
Loa Loa
Day 1: 1 mg/kg PO PC
Day 2: 1 mg/kg PO TId
Day 3: 1-2 mg/kg PO TId
Day 4-21: 9 mg/kg/day divided TId
Other Information
Pulmonary eosinophilia, tropical: See adult dosing
Larva migrans, visceral: See adult dosing
Available from Wyeth-Ayerst for compassionate use only: (610) 688-4400 or from CDC via compassionate INd
Hetrazan (diethylcarbamazine) adverse (side) effects
Frequency not defined
Encepholopathy (rare)
Fever
GI disturbances
Warnings
Contraindications
No studies reported
Pregnancy and lactation
Pregnancy category: X
Lactation: not known if excreted in breast milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Hetrazan (diethylcarbamazine)
Absorption: readily
Distribution: widely distributed throughout all body compartments, except adipose tissue
Half-life: 8 hr
Peak Plasma Time: 1-2 hr
Peak Plasma Concentration: (50 mg dose) 80-200 ng/mL
Metabolites: diethylcarbamazine N-oxide
Excretion: urine & feces
Mechanism of action
Microfilaricidal and macrofilaricidaL
