polyethylene glycol/electrolytes and bisacodyl (HalfLytely Bowel Prep Kit)
Classes: Laxatives, Osmotic; Laxatives, Stimulant
- Dosing and uses of HalfLytely Bowel Prep Kit (polyethylene glycol/electrolytes and bisacodyl)
- HalfLytely Bowel Prep Kit (polyethylene glycol/electrolytes and bisacodyl) adverse (side) effects
- Warnings
- Pregnancy
- Pharmacology of HalfLytely Bowel Prep Kit (polyethylene glycol/electrolytes and bisacodyl)
Dosing and uses of HalfLytely Bowel Prep Kit (polyethylene glycol/electrolytes and bisacodyl)
Adult dosage forms and strengths
October 7, 2016: Withdrawn from U.S. market; this drug is listed by the FDA as a product that has been withdrawn or removed from the market for reasons of safety or effectiveness
oral delayed-release tablet
- One 5-mg tablets in kit
oral powder for solution
- After reconstitution contains: 210 g PEG-3350, 2.86 g sodium bicarbonate, 5.6 sodium chloride, 0.74 g potassium chloride
Gastrointestinal Lavage
October 7, 2016: Withdrawn from U.S. market; this drug is listed by the FDA as a product that has been withdrawn or removed from the market for reasons of safety or effectiveness
Indicated for colon cleansing on day prior to colonoscopy
Bisacodyl: 5 mg PO with water; do NOT chew or crush the tablets
PEG/electrolyte solution: Wait for bowel movement stimulated by bisacodyl (or maximum of 6 hr), then drink 2 L of solution at rate of 8 oz q10minutes
Administration
PEG/electrolyte solution preparation
- Add flavor pack of choice (if applicable) to the 2 L container
- No additional ingredients (other than flavor packs provided) should be added to the solution
- Prepare the solution by filling the container to the 2 L mark with water
- Cap the container and shake to dissolve the powder
- To improve palatability; may prepare earlier the same day as ingested and refrigerate
- Drinking solution through straw and serving over ice also improves palatability
Pediatric dosage forms and strengths
Safety and efficacy not established
HalfLytely Bowel Prep Kit (polyethylene glycol/electrolytes and bisacodyl) adverse (side) effects
>10%
Nausea (34%)
Fullness (40%)
Cramping (38%)
1-10%
Vomiting
< 1%
Asystole
Aspiration
Dizziness
Ischemic colitis
Dyspnea
Dermatitis
Rhinorrhea
Seizure
Warnings
Contraindications
Hypersensitivity
GI obstruction
Bowel perforation
Gastric retention
Ileus
Toxic colitis
Toxic megacolon
Cautions
Generalized tonic-clonic seizures (reported rarely) with use of large volume (4 L) with no prior history of seizures; cases were associated with severe vomiting, excessive consumption, and electrolyte abnormalities (eg, hyponatremia, hypokalemia)
Monitor closely if impaired gag reflex or prone to regurgitation or aspiration
Use with caution in renal impairment and ulcerative colitis
If GI obstruction or perforation suspected, performed appropriate studies to rule out these conditions before administration
Ischemic colitis has been reported; if severe abdominal pain or rectal bleeding occurs, evaluate as soon as possible
If severe vomiting occurs, check serum electrolytes
Serious arrythmias reported
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown whether distributed in breast milk; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of HalfLytely Bowel Prep Kit (polyethylene glycol/electrolytes and bisacodyl)
Mechanism of action
Bisacodyl: stimulant laxative that acts directly on colonic mucosa to produce peristalsis
PEG/electrolyte solution: Elicits osmotic laxative effect and replenishes electrolytes; induces catharsis through strong electrolyte and osmotic effects