neomycin/polymyxin B/gramicidin ophthalmic (Gramicidin, Neosporin Ophthalmic Solution, Neocin-PG)

Dosing and uses of Gramicidin, Neosporin Ophthalmic Solution (neomycin/polymyxin B/gramicidin ophthalmic)

• Adult
• Pediatric

 

Adult dosage forms and strengths

ointment

• 3.5g

ophthalmic solution

• 10mL

 

Treatment & Prevention of Ocular Infection &/or Inflammation

Ointment: q3-4hr

Drops: 1-2 gtts q4hr for 7-10 days; if severe 2 gtts q1hr

 

Other Indications & Uses

Treatment of conjunctivitis of bacterial origin

Effective in combination with other topical agents for treatment of Acanthamoeba keratitis

 

Pediatric dosage forms and strengths

Same as adult dosing

 

Gramicidin, Neosporin Ophthalmic Solution (neomycin/polymyxin B/gramicidin ophthalmic) adverse (side) effects

Frequency not defined

Hypersensitivity

Itching, swelling, and conjunctival erythema

Local irritation

Allergic hypersensitivity

Anaphylaxis

 

Warnings

Contraindications

Aminglycoside/neomycin hypersensitivity; hypersensitivity to any component in product

 

Cautions

Watch for NEOMYCIN ocular sensitivity; drops contain gramacidin instead of bacitracin, since bacitracin not stable in solution

Combination of neomycin, polymixin and either gramacidin or bacitracin

 

Pregnancy and lactation

Pregnancy category: C

Lactation: safety in nursing infants unknown

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Gramicidin, Neosporin Ophthalmic Solution (neomycin/polymyxin B/gramicidin ophthalmic)

Mechanism of action

Inhibits bacterial cell wall synthesis by preventing the incorporation of amino acids and nucleotides into the cell walL