Glutathione (gamma-L-glutamyl-L-cysteinylglycine, GSH, L-glutathione, N-(N-L-gamma-glutamyl-L-cysteinyl)glycin...)

Suggested dosing of gamma-L-glutamyl-L-cysteinylglycine, GSH (glutathione)

 

Chemotherapy Adjunct

600 mg/d IM days 2-5 of chemotherapy

1.5 g/sq.meter IV before chemotherapy

 

Male Infertility

600 mg IM qOD x 2 months

 

Oral

250 mg PO qDay

Dose range: 50-600 mg/day

 

Inhaled

600 mg NEB BId

 

Inborn Errors of Metabolism of Glutathione (Orphan)

Liposomal glutathione: Support of glutathione deficiency in individuals with inborn errors of metabolism of glutathione (IEMG)

Orphan indication sponsor

• Your Energy Systems, LLC; 555 Bryant Street #305; Palo Alto, CA 94301

 

Cystic Fibrosis (Orphan)

S-Nitroglutathione: Management of cystic fibrosis to improve airway clearance and to improve or stabilize pulmonary function

Orphan indication sponsor

• N30 PHARMAceuticals, LLC; 3122 Sterling Circle; Boulder, CO 80301

 

Suggested uses of gamma-L-glutamyl-L-cysteinylglycine, GSH (glutathione)

Male infertility (IM use), atherosclerosis (IV, PO use), cancers, chemotherapy adjunct (IM, IV use), diabetes (IV use), immunostimulant, liver diseases, lung diseases (inhaled use), memory loss, Parkinson's disease (IV, PO use)

 

Efficacy

Possibly effective for chemotherapy toxicity

 

gamma-L-glutamyl-L-cysteinylglycine, GSH (glutathione) adverse (side) effects

Bronchospasm (inhaled use)

 

Warnings

Contraindications

Asthma (inhaled use)

 

Pregnancy and lactation

Pregnancy category: avoid use

Lactation: avoid use

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of gamma-L-glutamyl-L-cysteinylglycine, GSH (glutathione)

Metabolism: N/A

Excretion: N/A

 

Mechanism of action

Powerful antioxidant; co-factor in Phase I hepatic detoxification; involved in synthesis of DNA & proteins, amino acid transport, enzyme activation, immune system function