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pramoxine (Fleet Pain Relief, ProctoFoam NS, Tronolane, Tucks Ointment): Dosing and Uses

 

Classes: Gastrointestinal Agents, Other; Antipruritics/Non-corticosteroid Topical

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dosing and uses of Fleet Pain Relief, ProctoFoam NS (pramoxine)

 

Adult dosage forms and strengths

topicaL

  • 1%

 

Minor Skin Irritation

Apply lotion/cream to affected area up to 3-4 times/day

 

Vaginal Itching

Apply wipes to external vaginal area up to 3-4 times/day

 

Hemorrhoid Pain/Itching

Up to 5 times/day in anorectal area AM, PM and after bowel movements, or PRn

 

Pediatric dosage forms and strengths

topicaL

  • 1%

 

Minor Skin Irritation

< 2 years: Safety and efficacy not established

> 2 years: Apply lotion/cream to affected area up to 3-4 times/day

 

Hemorrhoidal or Vaginal Itching

< 12 years: Safety and efficacy not established

> 12 years: Apply lotion/cream to affected area up to 3-4 times/day

 

Fleet Pain Relief, ProctoFoam NS (pramoxine) adverse (side) effects

Frequency not defined

Irritation

Pruritus

 

Warnings

Contraindications

Hypersensitivity to any ingredients

 

Cautions

PR not to be used >4 consecutive weeks

Reevaluate if rectal bleeding or condition worsens in 7 days

 

Pregnancy and lactation

Pregnancy category: NA

Lactation: not known if excreted in breast milk

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Fleet Pain Relief, ProctoFoam NS (pramoxine)

Mechanism of action

Local anesthetic; inhibits conduction of nerve impulses from sensory nerves by decreasing neuronal membrane's permeability to sodium ions

 

Pharmacokinetics

Onset: 3-5 min