Dosing and uses of Fleet Bisacodyl Enema, Fleet Bisacodyl Suppository (bisacodyl rectal)
Adult dosage forms and strengths
enema
- 10mg/30mL
suppository
- 10mg
Constipation
Enema: Contents of 1 bottle (ie, 37 mL) rectally as a single dose
Suppository: Remove outer wrap and insert 1 suppository into rectum
Enema Administration
Patient should lie on left side with right knee bent
Gently insert enema tip into rectum using slight side-to-side movement; point enema tip toward navel (ease insertion by having patient bear down, as if having a bowel movement, to relax anal muscles)
Do not force enema tip into rectum
Squeeze bottle to deliver appropriate dose
Remove enema tip from rectum
Retain enema in accordance with doctor's instructions
Pediatric dosage forms and strengths
enema
- 10mg/30mL
suppository
- 10mg
Constipation
Enema
- >12 years: As adults; contents of 1 bottle (ie, 37 mL) rectally as a single dose
Suppository
- 6-12 years: Remove outer wrap and insert one-half suppository into rectum
- >12 years: As adults; remove outer wrap and insert 1 suppository into rectum
Fleet Bisacodyl Enema, Fleet Bisacodyl Suppository (bisacodyl rectal) adverse (side) effects
Frequency not defined
Abdominal cramping
Excessive diarrhea
Electrolyte and fluid imbalance
Rectal burning
Vertigo
Vomiting
Warnings
Contraindications
Hypersensitivity
Obstruction
Severe impaction
Symptoms of appendicitis or acute surgical abdomen
Vomiting
Rectal bleeding
Gastroenteritis
Cautions
Excessive use may cause electrolyte imbalance, steatorrhea, osteomalacia, diarrhea, & cathartic colon
Pregnancy and lactation
Pregnancy category: N/A
Lactation: Excretion in milk unknown
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Fleet Bisacodyl Enema, Fleet Bisacodyl Suppository (bisacodyl rectal)
Mechanism of action
May irritate the colonic intramural plexus of the intestine; alters water and electrolyte secretion, which in turn produces net intestinal fluid accumulation and laxation
Pharmacokinetics
Onset of action: 15-60 min
Half-life: 8 hr (BHPM metabolite)
Metabolism: Metabolized to BHPM in the colon
Excretion: Urine (BHPM) and bile
