Dosing and uses of Feridex (ferumoxides)
Adult dosage forms and strengths
injectable solution
- 11.2mg Fe/mL
Adjunct MRI Enhancement Agent
Used in detection & evaluation of liver lesions associated w/ reticuloendothelial system (RES) alteration
0.56 mg Fe/kg (0.05 mL/kg) in 100 mL D5W IV infusion over 30 min
Administration
Use vial at room temp
Dilute Feridex IV by injecting it into 100 mL D5W
Use diluted drug within 3 hr
Administer at 2-4 mL/min over 30 min through 5 micron filter
Do NOT administer undiluted
Pediatric dosage forms and strengths
Safety & efficacy not established
Warnings
Contraindications
Known allergy or hypersensitivity to iron; parenteral dextran, iron-dextran, or iron-polysaccharide preparations
Cautions
Risk of serious, life-threatening, fatal, anaphylactic-like reactions & hypotension
Risk of cardiovascular reactions
Autoimmune disease, iron overload disorder, acute severe back, leg or groin pain
Patients w/ Fe over load disorder (hemosiderosis, chronic hemolytic anemia w/ frequent blood transfusions)
Repeat Procedures: repeat images may be obtained up to 3.5 hrs after original infusion w/out reinjection
Pregnancy and lactation
Pregnancy category: C
Lactation: Excretion in milk unknown/not recommended unless benefits outweigh risks
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
