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phosphorated carbohydrate (Emetrol)

 

Classes: Antiemetic Agents

Dosing and uses of Emetrol (phosphorated carbohydrate)

 

Adult dosage forms and strengths

dextrose/fructose/phosphoric acid

solution, oraL

  • 1.87g/1.87g/21.5mg/5mL

 

Nausea

15-30 mL PO q15min until vomiting stops; not to exceed 5 doses/hr

 

Pediatric dosage forms and strengths

 

Nausea

<2 years old: Safety and efficacy not established

2-12 years old: 5-10 ml PO q15min until vomiting stops; not to exceed 5 doses/hr

>12 years old: 15-30 mL PO q15min until vomiting stops; not to exceed 5 doses/hr

 

Geriatric dosage forms and strengths

 

Nausea

15-30 mL PO q15min until vomiting stops; not to exceed 5 doses/hr

 

Emetrol (phosphorated carbohydrate) adverse (side) effects

Frequency not defined

Abdominal pain

Diarrhea

 

Warnings

Contraindications

Hypersensitivity, diabetes, fructose intolerance

 

Cautions

Avoid in diabetic patients (carbohydrate content)

Do not ingest fluids at least 15 min after taking product

 

Pregnancy and lactation

Pregnancy category: NA

Lactation: no studies

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Emetrol (phosphorated carbohydrate)

Mechanism of action

Hyperosmolar carbohydrate solution that has a direct effect on the GI tract wall; reduces GI smooth muscle contraction