Dosing and uses of Emadine (emedastine)
Adult dosage forms and strengths
ophthalmic solution
- 0.05%
Allergic Conjunctivitis
1 gtt in affected eye(s), maximum QId
Pediatric dosage forms and strengths
ophthalmic solution
- 0.05%
Allergic Conjunctivitis
<3 years old: Safey & efficacy not established
>3 years old: As adults; 1 gtt in affected eye(s), maximum QId
Emadine (emedastine) adverse (side) effects
>10%
Headache (11%)
1-10%
Blurred vision
Corneal infiltrates
Corneal staining
Dry eye
Foreign body sensation
Keratitis
Ocular burning or stinging
Ocular discomfort
Ocular hyperemia
Ocular pruritus
Tearing
Abnormal dreams
Asthenia
Bad taste
Dermatitis
Rhinitis
Sinusitis
Warnings
Contraindications
Hypersensitivity
Contact lens-related irritation
Cautions
Do not wear contact lenses if eyes are red; wait 10 min after emedastine to insert contacts
Pregnancy and lactation
Pregnancy category: B
Lactation: not known if distributed in milk; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Emadine (emedastine)
Absorption: extremely low systemic exposure
Half-Life: 3-4 hr
Metabolism: liver
Excretion: kidney
Mechanism of action
Histamine H1 antagonist, inhibits vascular permeability
