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aluminum chloride topical (Drysol, Xerac AC, Hypercare Solution)

 

Classes: Astringents

Dosing and uses of Drysol, Xerac AC (aluminum chloride topical)

 

Adult dosage forms and strengths

topical solution

  • 35mL (6.25% in 96% ethanol)
  • 35mL (20% in 93% ethanol)
  • 37.5mL (20% in 93% ethanol)
  • 60mL (6.25% in 96% ethanol)
  • 60mL (20% in 93% ethanol)

 

Hyperhidrosis

Indicated for severe, recalcitrant hyperhidrosis

Apply to affected area qDay at bedtime; once excessive sweating decreases (typically after 2 or more treatments), decrease application to 1-2 times/week

May cover treated area with plastic wrap held in place by tight fitting t-shirt, mitten, or sock; do not hold in place with tape

 

Other Information

Apply to completely dry skin to avoid irritation

Do not apply to broken, irritated, or recently shaved skin

20% suitable for axillae, palms, and soles

 

Pediatric dosage forms and strengths

topical solution

  • 35mL (6.25% in 96% ethanol)
  • 35mL (20% in 93% ethanol)
  • 37.5mL (20% in 93% ethanol)
  • 60mL (6.25% in 96% ethanol)
  • 60mL (20% in 93% ethanol)

 

Hyperhidrosis

Infants and children: Safety and efficacy not established

Adolescents: As adults

Indicated for severe, recalcitrant hyperhidrosis

Apply to affected area qDay at bedtime; once excessive sweating decreases (typically after 2 or more treatments), decrease application to 1-2 times/week

May cover treated area with plastic wrap held in place by tight fitting t-shirt, mitten, or sock; do not hold in place with tape

 

Other Information

Apply to completely dry skin to avoid irritation

Do not apply to broken, irritated, or recently shaved skin

20% suitable for axillae, palms, and soles

 

Drysol, Xerac AC (aluminum chloride topical) adverse (side) effects

Frequency not defined

Irritation

Itching

Tingling

 

Warnings

Contraindications

Hypersensitivity

 

Cautions

Do not apply to broken, irritated, or recently shaved skin

Discontinue use if irritation/sensitization occurs

External use only; avoid eyes

May harm certain metals or fabrics

Flammable: Do not use near open flame

 

Pregnancy and lactation

Pregnancy category: C

Lactation: Unknown whether distributed in breast milk, caution advised

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Drysol, Xerac AC (aluminum chloride topical)

Mechanism of action

Astringent