MSM (dimethyl sulfone, DMSO2, methylsulfonylmethane, Glucosamine and Chondroitin with MSM, Flex-a-min, MSM glucosamine chondroitin, Osteo BiFlex plus MSM, Triflex)
Classes: Analgesics, Herbals; Dermatology, Herbals; Neurology & Psychiatry, Herbals
Dosing and uses of dimethyl sulfone, DMSO2 (MSM)
Adult dosage forms and strengths
1000-3000 mg/day, divided, or
400 mg per 50 lbs body weight per day
Take with meals
Other Indications & Uses
Oral and topical: Chronic musculoskeletal & joint pain, scars, wrinkles, periodontal disease, wound healing
Oral: Allergies, depression, peptic ulcer, interstitial cystitis, type 2 DM, lung dysfunction, HIV infection
Efficacy
- Insufficient information
Pediatric dosage forms and strengths
Safety and efficacy not established
dimethyl sulfone, DMSO2 (MSM) adverse (side) effects
Frequency not defined
Nausea
Diarrhea
Headache
Bloating
Fatigue
Insomnia
Difficulty concentrating
Warnings
Contraindications
Hypersensitivity
Pregnancy and lactation
Pregnancy category: Unknown; avoid use
Lactation: Unknown; avoid use
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of dimethyl sulfone, DMSO2 (MSM)
Metabolism: N/A
Excretion: N/A
Mechanism of action
Breakdown product of dimethyl sulfoxide (DMSO); precursor source of sulfur for cysteine and methionine
