miconazole topical (Desenex, Fungoid Tincture, Monistat Derm, Micatin, Zeasorb-AF, Cavilon Antifungal Cream)
Classes: Antifungals, Topical
Dosing and uses of Desenex, Fungoid Tincture (miconazole topical)
Adult dosage forms and strengths
cream/aerosol powder & spray/tincture
- 2%
Tinea
Tinea cruris, corporis & cutaneous canidiasis: Apply to affected area BID x2 weeks
Tinea versicolor: Apply qDay to affected area x2 weeks
Tinea pedis: Apply BID to affected area x4 weeks
Otitis Externa (Orphan)
Orphan designation for treatment of fungal otitis externa (otomycosis)
Sponsor
- Hill Dermaceuticals, Inc; 2650 S. Mellonville Ave; Sanford, FL 32773-9311
Pediatric dosage forms and strengths
cream/aerosol powder & spray/tincture
- 2%
Tinea
<2 years: Safety and efficacy not established
≥2 years: Apply topical cream or powder BID for up to 1 month
Desenex, Fungoid Tincture (miconazole topical) adverse (side) effects
Frequency not defined
Irritation
Burning
Maceration
Allergic contact dermatitis
Irritation, burning, maceration, allergic contact dermatitis (all rare)
Warnings
Contraindications
Hypersensitivity
Pregnancy and lactation
Pregnancy category: C
Lactation: not known whether distributed into milk; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Desenex, Fungoid Tincture (miconazole topical)
Absorption: none
Enzymes inhibited: hepatic CYP3A4
Mechanism of action
Exerts its antifungal and antibacterial activity by altering cell membrane permeability; its site of action on cell membranes has not been elucidated
As a result of this alteration of permeability, the cell membrane is unable to function as a selective barrier, and potassium and other cellular constituents are lost
