Dosing and uses of Dermatop (prednicarbate)
Adult dosage forms and strengths
cream/ointment
- 0.1%
Dermatoses
Apply cream BId
Not for use >3 weeks
Other Indications & Uses
Inflammatory/pruritic dermatoses, eczemas, lichen planus, burns (1st and 2nd degree)
Adjunctive treatment for: alopecia areata, chronic discoid lupus erythematosus, dysidrosis, familial benign pemphigus, mycosis fungoides, nodular prurigo, psoriasis, seborrheic dermatitis
Pediatric dosage forms and strengths
cream/ointment
- 0.1%
Dermatoses
<12 months old: Safety & efficacy not established
>12 months old: apply cream BId
Not for use >3 weeks
Limit to minimum amount necessary for therapeutic efficacy
Other Indications & Uses
Inflammatory/pruritic dermatoses, eczemas, lichen planus, burns (1st and 2nd degree)
Adjunctive treatment for: alopecia areata, chronic discoid lupus erythematosus, dysidrosis, familial benign pemphigus, mycosis fungoides, nodular prurigo, psoriasis, seborrheic dermatitis
Dermatop (prednicarbate) adverse (side) effects
Frequency not defined
Skin atrophy
Striae
Acneform lesions
Pigmentation changes
HPA suppression (with higher potency used >2 wk)
Warnings
Contraindications
Underlying infection
Hypersensitivity
Ophthalmic use
Cautions
Chronic topical corticosteroid therapy may interfere with growth & development in children
Use medium to very high potency for <2 wk to reduce local and systemic side effects
Use low potency for chronic therapy
Avoid medium to very high potency on face, folds, groin because can increase steroid absorption
Use lower potency for children (ie, increase BSA/kg, therefore increase systemic absorption)
Avoid contact between cream/ointment and latex containing products (eg, condoms, diaphragm); paraffin in cream/ointment can cause damage to latex and reduce the effectiveness of any latex containing products
Externally only, not for intravaginally use
Pregnancy and lactation
Pregnancy category: C
Lactation: not known whether topical corticosteroids are distributed into milk; however, systemic corticosteroids are distributed into milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Dermatop (prednicarbate)
Absorption: yes
Potency: medium (cream)
Potency
Medium (cream)
Relative potency: ointment >cream >lotion >solution
Very-high: clobetasol, diflorasone diacetate ointment 0.05%, halobetasoL
High: betamethasone dipropionate 0.05%, amcinonide, fluocinonide, desoximetasone, mometasone, diflorasone emollient 0.05%, halcinonide
Medium: triamcinolone, betamethasone valerate 0.1%, fluticasone, flurandrenolide, fluocinolone 0.025%, hydrocortisone
Mild: hydrocortisone 0.5, 1, 2.5% base, desonide, alclometasone
Mechanism of action
Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation
