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pyrithione zinc (Denorex Everyday Dandruff Shampoo, Head and Shoulders Shampoo, DHS Zinc Shampoo, Head and Shoulders Dry Scalp, Selsun Blue Itchy Dry Scalp, T/Gel Daily Control, Zincon Shampoo): Dosing and Uses

 

Classes: Keratolytic Agents

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dosing and uses of Denorex Everyday Dandruff Shampoo, Head and Shoulders Shampoo (pyrithione zinc)

 

Adult dosage forms and strengths

shampoo

  • 0.25%
  • 1%
  • 2%

 

Seborrhea

Apply shampoo to wet hair/scalp, lather, then rinse welL

 

Pediatric dosage forms and strengths

Safety and efficacy not established

 

Denorex Everyday Dandruff Shampoo, Head and Shoulders Shampoo (pyrithione zinc) adverse (side) effects

Frequency not defined

Stinging/burning of scalp

Desquamation

 

Warnings

Contraindications

Hypersensitivity

 

Cautions

Topical use only

Avoid contact with eyes

 

Pregnancy and lactation

Pregnancy category: C

Lactation: unknown

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Denorex Everyday Dandruff Shampoo, Head and Shoulders Shampoo (pyrithione zinc)

Mechanism of action

Keratolytic agent