carbamide peroxide otic (Debrox, Murine Ear Wax Removal, Auro Ear Drops, ERO Ear)
Classes: Otics, Other
Dosing and uses of Debrox, Murine Ear Wax Removal (carbamide peroxide)
Adult dosage forms and strengths
ear drops
- 6.5%
- 10%
Softening, Loosening, & Removing Excessive Ear Wax
Instill 5-10 gtt in ear canal twice daily; not to exceed use beyond 4 days
Keep drops in ear for several minutes by tilting the head sideways and placing a cotton in ear
Kit comes with ear syringe
Pediatric dosage forms and strengths
ear drops
- 6.5%
- 10%
Softening, Loosening, & Removing Excessive Ear Wax
<12 years: Instill 1-5 gtt in ear canal twice daily
>12 years: Instill 5-10 gtt in ear canal twice daily
Keep drops in ear for several minutes by tilting the head sideways and placing a cotton in ear
Not to exceed use beyond 4 days
Kit comes with ear syringe
Debrox, Murine Ear Wax Removal (carbamide peroxide) adverse (side) effects
Frequency not defined
Hypersensitivity
Minor irritation
Rash
Redness
Superinfection
Warnings
Contraindications
Hypersensitivity
Perforated tympanic membrane, discharge or pain, irritation or rash in the ear, use in eye
Cautions
Patient instructions: do not use if ear drainage, discharge, pain, irritation, or rash occurs
If dizzy, consult healthcare professionaL
Do not use if perforation or injury of ear drum exists or after ear surgery unless directed to do so
Do not generally use for >4 days
May flush remaining wax out with warm water and rubber ear syringe
Not for use as OTC medication for patients < 2 years
Pregnancy and lactation
Pregnancy category: C
Lactation: Safe
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Debrox, Murine Ear Wax Removal (carbamide peroxide)
Mechanism of action
Deodorant action, probably by inhibiting odor-causing bacteria
Mild mechanical loosening effect on cerumen (earwax) that has been softened by anhydrous glycerin
