Dosing and uses of Cortisporin Otic (hydrocortisone-neomycin-polymyxin)
Adult dosage forms and strengths
hydrocortisone/neomycin/polymyxin otic
otic solution
- 10mg (1%)/3.5mg (0.35%)/10000units/10mL
Superficial Bacterial Infections of External Auditory Canal
4 drops in ear q6-8hr
Bacterial Infections of Mastoidectomy & Fenestration Cavities
4 drops in ear q6-8hr
Pediatric dosage forms and strengths
hydrocortisone/neomycin/polymyxin otic
solution
- 10mg (1%)/3.5mg (0.35%)/10000units/10mL
Superficial Bacterial Infections of External Auditory Canal
3 drops in ear q6-8hr
Bacterial Infections of Mastoidectomy & Fenestration Cavities
3 drops in ear q6-8hr
Cortisporin Otic (hydrocortisone-neomycin-polymyxin) adverse (side) effects
Frequency not defined
Hypersensitivity
Itching
Redness
Skin rash
Swelling
Warnings
Contraindications
Hypersensitivity to any agent
Patients with herpes simplex, vaccinia, and varicella infections
Cautions
Patients may develop hypersensitivity to neomycin component in particular
Solution does not penetrate quite as well as suspension does
Pediotic has more neutral pH, with less stinging and burning
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown whether drug is excreted in milk; use with caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Cortisporin Otic (hydrocortisone-neomycin-polymyxin)
Mechanism of action
Hydrocortisone: Suppresses inflammatory response
Neomycin: Inhibits protein synthesis
Polymyxin: Bactericidal; active against gram-negative bacteria; disrupts bacterial cytoplasmic membrane structure and alters membrane permeability to allow leakage of intracellular contents
Absorption
Agent is absorbed if eardrum is perforated or tissue damage is present
