Coenzyme Q10 (CoQ10, ibedenone, mitoquinone, ubidecarenone, ubiquinone, vitamin Q10)

Suggested dosing of CoQ10, ibedenone (coenzyme Q10)

50-200 mg PO daily

CHF: 100 mg/day div BID-TID PO

Myocardial preservation for heart surgery: 200 mg/day PO

 

Suggested uses of CoQ10, ibedenone (coenzyme Q10)

Angina, chronic fatigue syndrome, CHF, diabetes mellitus, doxorubicin-induced cardiotoxicity (prevention), HIV/AIDS immunostimulant, hypertension, mitochondrial cytopathies, muscular dystrophies, myopathy (statin-induced)

Efficacy may be effective in CHF, MI, mitochondrial encephalomyopathies

Reduces BP; more studies need before recommendation in hypertension

Inconclusive for stable angina, cardiomyopathy, periodontal disease

 

Huntington's Disease (Orphan)

Orphan indication sponsors

• Integrative Therapeutics, Inc; 825 Challenger Drive; Green Bay , WI 54311
• Gel-Tec, Division of Tishcon Corp; 30 New York Avenue; PO Box 331; Westbury, NY 11590

 

Mitochondrial Cytopathies (Orphan)

Orphan indication sponsor

• Gel-Tec, Division of TISHCON Corporation; 30 New York Avenue; PO Box 331; Westbury, NY 11590

 

Pediatric Congestive Heart Failure (Orphan)

Orphan indication sponsor

• Gel-Tec, Division of TISHCON Corporation; 30 New York Avenue; PO Box 331; Westbury, NY 11590

 

CoQ10, ibedenone (coenzyme Q10) adverse (side) effects

Frequency not defined

Diarrhea

Appetite decreased

Elevated LFTs

Gastric distress

Nausea

 

Warnings

Cautions

Biliary obstruction, concurrent antihypertensives, concurrent cancer chemotherapy, concurrent radiation therapy, hepatic insufficiency, hypertension

 

Pregnancy and lactation

Pregnancy category: N/A

Lactation: N/A

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of CoQ10, ibedenone (coenzyme Q10)

Metabolism: N/A

Excretion: N/A

 

Mechanism of action

Ubiquinone: involved in electron transport chain

Ubiquinol: antioxidant, membrane stabilizer