Suggested dosing of Citrus paradisi, pomelo (grapefruit)
No typical dosage
>4 glasses juice/day for pharmacologic effects Or
1 to 9 glasses daily, or 240 mL of double-strength juice BId
Suggested uses of Citrus paradisi, pomelo (grapefruit)
Atherosclerosis, asthma, atopic dermatitis, cancer, fiber supplement, hematocrit reduction, hypercholesterolemia, potassium supplement, psoriasis, vitamin C supplement, weight loss aid
Efficacy
Insufficient reliable evidence
Citrus paradisi, pomelo (grapefruit) adverse (side) effects
Decreased hematocrit
Warnings
Contraindications
None reported
Cautions
Concurrent CYP3A4 substrates
Concurrent interactive agents
Pregnancy and lactation
Pregnancy category: avoid excess
Lactation: avoid excess
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Citrus paradisi, pomelo (grapefruit)
Metabolism: N/A
Excretion: N/A
Enzyme Inhibited: CYP3A4
Mechanism of action
Source of potassium, vit C, pectin
Pectin decrease cholesterol & promote regression of atherosclerosis
