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calcium citrate (Cal-Cee, Cal-C-Cap)

 

Classes: Calcium Salts

Dosing and uses of Citracal (calcium citrate)

 

Adult dosage forms and strengths

tablet/capsule

  • 150mg
  • 200mg
  • 250mg
  • 950mg
  • 1040mg

Granules

  • 760mg/3.5g

 

RDA (Elemental Calcium)

<50 years: 1 g/day

>50 years females: 1.2 g/day

>50 years males: 1 g/day

>70 years males: 1.2 g/day

 

Hypocalcemia Prevention

1 g/day in divided doses

 

Primary Osteoporosis Prevention

1-1.5 g/day in divided doses

 

Other Information

211 mg elemental Ca per gram of calcium citrate

Most commercial products also contain Vitamin d

 

Other Indications & Uses

Oral Ca supplements may protect against renal calculi formation by chelating with oxalate in gut and preventing its absorption

 

Pediatric dosage forms and strengths

tablet/capsule

  • 150mg
  • 200mg
  • 250mg
  • 950mg
  • 1040mg

Granules

  • 760mg/3.5g

 

RDA (Elemental Calcium)

<6 months old: 200 mg/day

6-12 months old: 260 mg/day

1-3 years old: 700 mg/day

4-8 years old: 1000 mg/day

9-18 years old: 1300 mg/day

 

Hypocalcemia

Neonates: 50-150 mg/kg/day divided q4-6hr PO; dose expressed as elemental calcium; no more than 1g/day

Children: 45-65 mg/kg/day divided q6hr PO; dose expressed as elemental calcium

 

Citracal (calcium citrate) adverse (side) effects

Frequency not defined

Hypotension

Headache

Constipation

Diarrhea

Flatulence

Nausea

Vomiting

Hypophosphatemia

Hypomagnesemia

Hypercalcemia

  • Anorexia
  • Coma
  • Confusion
  • Delirium
  • Headache
  • Lethargy
  • Milk-alkali syndrome (very high, chronic dosing)
  • Nausea/Vomiting

 

Warnings

Contraindications

Documented hypersensitivity, hypercalciuria, renal calculi, hypophosphatemia, hypercalcemia, ventricula fibrillation

 

Cautions

Hypercalcemia and hypercalciuria may result from long term use

Advise patients to limit intake of oxalate-rich foods (soy, green leafy vegetables, animal protein) to avoid reduced absorption through Ca-oxalate formation

 

Pregnancy and lactation

Pregnancy category: C

Lactation: safe, crosses the placenta; appears in breast milk

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Citracal (calcium citrate)

Mechanism of action

Dietary supplement: prevents or treats negative Ca balance