Resveratrol (cis-resveratrol, kojo-kon, Stilbene phytoalexin, trans-resveratrol)

Suggested dosing of Cis-resveratrol, kojo-kon (resveratrol)

10-200 mg/day PO

 

Suggested uses of Cis-resveratrol, kojo-kon (resveratrol)

Atherosclerosis, hypercholesterolemia, cancer prevention

 

Cis-resveratrol, kojo-kon (resveratrol) adverse (side) effects

None reported

 

Warnings

Contraindications

Hypersensitivity

Pregnancy (red wine)

 

Cautions

None reported

 

Pregnancy and lactation

Pregnancy category: avoid red wine

Lactation: unknown; not recommended

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Cis-resveratrol, kojo-kon (resveratrol)

Metabolism: N/A

Excretion: N/A

 

Mechanism of action

Polyphenol found in grape skins, dark red wines; supplements usually derived from Japanese knotweed (Polygonium cuspidatum)

Antioxidant, antiplatelet, antimutagenic, and phytoestrogenic properties

Inhibits COX 1 & 2 and 5-lipoxygenase