Resveratrol (cis-resveratrol, kojo-kon, Stilbene phytoalexin, trans-resveratrol)
Classes: Cardiovascular, Herbals; Oncology, Herbals
Suggested dosing of Cis-resveratrol, kojo-kon (resveratrol)
10-200 mg/day PO
Suggested uses of Cis-resveratrol, kojo-kon (resveratrol)
Atherosclerosis, hypercholesterolemia, cancer prevention
Cis-resveratrol, kojo-kon (resveratrol) adverse (side) effects
None reported
Warnings
Contraindications
Hypersensitivity
Pregnancy (red wine)
Cautions
None reported
Pregnancy and lactation
Pregnancy category: avoid red wine
Lactation: unknown; not recommended
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Cis-resveratrol, kojo-kon (resveratrol)
Metabolism: N/A
Excretion: N/A
Mechanism of action
Polyphenol found in grape skins, dark red wines; supplements usually derived from Japanese knotweed (Polygonium cuspidatum)
Antioxidant, antiplatelet, antimutagenic, and phytoestrogenic properties
Inhibits COX 1 & 2 and 5-lipoxygenase
