Dosing and uses of ChiRhoStim (secretin)
Adult dosage forms and strengths
powder for injection
- 16 mcg/vial
Pancreas Dysfunction
Secretin stimulation testing for diagnosis of pancreatic exocrine dysfunction
0.2 mcg/kg IV over 1 minute
Gastrinoma
Secretin stimulation testing for diagnosis of gastrinoma
0.4 mcg/kg IV over 1 minute
Ampulla of Vater & Accessory Papilla
Secretin stimulation testing for identification of ampulla of Vater and accessory papilla during ERCp
0.2 mcg/kg IV over 1 minute
Pediatric dosage forms and strengths
Safety and efficacy not established
ChiRhoStim (secretin) adverse (side) effects
<1%
Hypotension
Diaphoresis
Flushing
Abdominal pain
Bleeding
Abdominal cramps
Bloating
Bradycardia
Nausea
Warnings
Contraindications
Hypersensitivity
Acute pancreatitis
Cautions
Test dose of 0.2 mcg (0.1 ml) IV to check for allergic reaction (wait 1 min)
Prior vagotomy, current anticholinergic prescription, or IBD may blunt response to secretin stimulation
Alcoholic or other liver disease may lead to greater than normal volume in response to secretin stimulation
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of ChiRhoStim (secretin)
Mechanism of action
Peptide hormone; increase volume and bicarb content of pancreatic secretions
Pharmacokinetics
Half-Life: 27 min
Vd: 2 L
Total Body Clearance: 487±136 mL/min
Administration
IV Administration
Reconstitute by adding 8 mL of NS to a vial containing 16 mcg of secretin to yield 2 mcg/mL; shake vigorously to ensure complete dissolution
Slow IV injection over 1 min
Storage
Store at -20°C
