Dosing and uses of Cenolate, Vitamin C (ascorbic acid)
Adult dosage forms and strengths
tablets
- 100mg
- 250mg
- 500mg
- 1g
chewable, tablet
- 100mg
- 250mg
- 500mg
capsule, extended release
- 500mg
tablet, extended release
- 500mg
- 1000mg
- 1500mg
crystals
- 120g
- 480g
granules
- 100g
- 500g
- 1000g
injectable solution
- 250mg/mL
- 500mg/mL
oral solution
- 100mg/mL
powder effervescent
- 150g
powder, oraL
- 113mg
- 120mg
- 480mg
water, oraL
- 500mg
syrup, oraL
- 100mg/mL
RDa
Males: 90 mg/day
Females: 75 mg/day
Pregnant: 85 mg/day; not to exceed 2000 mg/day (80 mg if <18 years; not to exceed 1800 mg/day)
Nursing: 120 mg/day; not to exceed 2000 mg/day (115 mg if <18 years old; not to exceed 1800 mg/day)
Urinary Acidification
4-12 g/day PO/IV divided three or four times daily
Macular Degeneration (Off-label)
500 mg/day PO with other vitamins and minerals
Ascorbic Acid Deficiency (Scurvy) (Orphan)
100 to 250 mg (0.2 to 0.5 mL ascorbic acid), PO/IV qDay/BID for at least 2 weeks
Extreme deficiency: 1-2 g (2 to 4 mL)
Orphan indication sponsor
- McGuff Pharmaceuticals Inc; 2921 W. McArthur Blvd, Suite 141; Santa Ana, CA 92704-6929
Charcot-Marie-Tooth Disease (Orphan)
Designated orphan indication for Charcot-Marie-Tooth disease type 1A
Orphan designated sponsor
- Murigenetics SAS; Faculte de Medecine Timone; 13005 Marseille, France
Pediatric dosage forms and strengths
tablets
- 100mg
- 250mg
- 500mg
- 1g
chewable, tablet
- 100mg
- 250mg
- 500mg
capsule, extended release
- 500mg
tablet, extended release
- 500mg1000mg1500mg
crystals
- 120g
- 480g
granules
- 100g
- 500g
- 1000g
injectable solution
- 250mg/mL
- 500mg/mL
oral solution
- 100mg/mL
powder effervescent
- 150g
powder, oraL
- 113mg
- 120mg
- 480mg
water, oraL
- 500mg
syrup, oraL
- 100mg/mL
RDa
0-6 months: 40 mg/day
6-12 months: 50 mg/day
1-3 years: 15 mg/day
3-8 years: 25 mg/day
8-13 years: 45 mg/day
13-18 years: (male) 75 mg/day; (female) 65 mg/day
UL: 1-3 years: 400 mg/day; 4-8 years old: 600 mg/day; 9-13 years old: 1.2 g/day; 12-18 years old: 1.8 g/day
Urinary Acidification
500 mg/day divided PO/IV TID/QId
Ascorbic Acid Deficiency (Scurvy) (Orphan)
100-300 mg/day PO/IV/IM/SC divided BId
Orphan indication sponsor
- McGuff Pharmaceuticals Inc; 2921 W. McArthur Blvd, Suite 141; Santa Ana, CA 92704-6929
Charcot-Marie-Tooth Disease (Orphan)
Designated orphan indication for Charcot-Marie-Tooth disease type 1A
Orphan designated sponsor
- Murigenetics SAS; Faculte de Medecine Timone; 13005 Marseille, France
Cenolate, Vitamin C (ascorbic acid) adverse (side) effects
Frequency not defined
Flushing
Flank pain
Faintness, headache
Diarrhea, dyspepsia, nausea, vomiting
Hyperoxaluria (large doses)
Warnings
Contraindications
Hypersensitivity
Cautions
Renal impairment, G6PD deficiency (high doses)
Use of parenteral preparation in nursing women
Patients with history of renal calculi should avoid taking excessive doses for extended periods of time
Solutions exposed to air rapidly oxidized
Patients with diabetes mellitus should not take excessive doses for extended periods of times
Destroyed by sunlight
Pregnancy and lactation
Pregnancy category: A (dose within RDA); C (dose exceeding RDA recommendation)
Lactation: Enters breast milk/compatible
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Nutrition
Sources: Citrus fruits, peppers, cabbage, papaya, orange juice, broccoli, guava, carambola, radishes
Function: Required for collagen biosythesis
Deficiency: Scurvy; fatigue, depression, easy bruising & bleeding, weakened cartilage, coiled hairs, difficulty wound healing, thickened skin, abnormal bone growth in infants
Toxicity: Potential for kidney stones, withdrawal from high doses can lead to scurvy, even with "normal" intake
Pharmacology of Cenolate, Vitamin C (ascorbic acid)
Mechanism of action
Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid
Pharmacokinetics
Distribution: Large
Metabolism: Liver
Absorption: Rapidly absorbed
Excretion: Urine
Administration
When oral administration is not feasible or when malabsorption is suspected
IM preferred to IV
IV Preparation
Dilute with large volume of compatible fluid to minimize adverse reactions
Compatible w/ most common diluents (dextrose solns, NS, LR, Ringer's, ½NS, dextrose-saline, dextrose-LR etc)
IV Administration
Avoid rapid infusion
