Celandine (celandine poppy, chelidonium majus, greater celandine, tetterwort, Ukrain)

Suggested dosing of Celandine poppy, chelidonium majus (celandine)

Average 2-5 g/day

 

Ukrain: 5-20 mg parenterally qD-q3d

Cancer: 50-300 mg IV qDay, with 100 mg IV qday most common

Available in Europe & Mexico & alternative/complementary health centers in the Us

 

Dyspepsia

Oral: 1 mL TId

 

Suggested uses of Celandine poppy, chelidonium majus (celandine)

Intestinal spasms, dyspepsia, liver disease, prevention of gallstone formation

Ukrain (celandine+thiotepa): cancers

 

Efficacy

Approved by German Commission E for intestinal spasms

Ukrain has selective cytotoicity against neoplastic cells in vitro; also some positive results but in small & possibly poorly-designed clinical studies

 

Celandine poppy, chelidonium majus (celandine) adverse (side) effects

Rashes, itching, serious allergic reactions

 

Warnings

Contraindications

Pregnancy, breastfeeding

 

Cautions

Potential risk of hepatitis

Parts of the plant (esp roots) may be toxic

 

Pregnancy and lactation

Pregnancy category: avoid

Lactation: avoid

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Celandine poppy, chelidonium majus (celandine)

Metabolism: N/A

Excretion: N/A

 

Mechanism of action

Strong cholagogue