Dosing and uses of Cefpirome
Adult dosage forms and strengths
Not available in the U.S.A
1-4 g IV q12hr
Renal Impairment
CrCl 20-50 mL/min: 1-2 g load, 0.5-1 g IV BId
CrCl 5-20 mL/min: 1-2 g load, 0.5-1 g IV qDay
CrCl <5 mL/min 0.25-0.5 g qDay
Other Information
Inject or infuse over 30 minutes
Other Indications & Uses
Anaerobic cocci, Bacteroides spp., Enterobacter spp., E. coli, H. influenzae, Klebsiella spp., M. catarrhalis, M. morganii, Providencia rettgeri, Pseudomonas spp., Serratia spp., S. aureus, S. pneumoniae, S. pyogenes
Pediatric dosage forms and strengths
Not available in the U.S.A.
Not recommended
Cefpirome adverse (side) effects
<1%
Colitis
Diarrhea
Dyspnea
Headache
Phlebitis
Rash
Vaginitis
Vomiting
Warnings
Contraindications
Hypersensitivity to cephalosporins, penicillins
Concomitant live bacterial vaccines
Pregnancy and lactation
Pregnancy category: C
Lactation: excreted in breast milk; unsure if safe; do not use
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Cefpirome
Half-Life: 1.8-2.2 hr
Peak plasma: 5 min
Excretion: urine
Administration
IV Compatibilities
Y-site: amikacin, amphotericin B, cefazolin, clindamycin, dexamethasone sodium phosphate, dopamine, fluconazole, gentamicin, vancomycin
IV Administration
Administer by IV inj over 3-5 min, Or
By intermittent infusion over 20-30 min
Storage
Store at 25°C
Protect from light
